Alginate films containing pyrogenic silica supported silver nanoparticles were prepared as potential wound dressings. First silica supported silver nanoparticles (CAB-O-SIL-Ag) were prepared via solid state sintering route without the use of any solvent and reducing agent. The obtained composite was characterized by X-ray powder diffraction, transmission electron microscopy and UV–vis spectroscopy which evidenced the presence of 8–20 nm spherical silver nanoparticles uniformly distributed and grown on the silica surface. Then the CAB-O-SIL-Ag was used as filler to prepare alginate films by casting method and successive gelation. Films with two different silver concentrations were prepared. They showed good hydration properties and a very slow silver release. Films exhibited antimicrobial and antibiofilm activities against Staphylococcus aureus and Pseudomonas aeruginosa and showed no cytotoxicity towards human skin keratinocytes and human fibroblasts HuDe.

制备含有热解二氧化硅负载的银纳米颗粒的藻酸盐膜作为潜在的伤口敷料。通过固态烧结途径制备第一二氧化硅负载的银纳米颗粒（CAB-O-SIL-Ag），而无需使用任何溶剂和还原剂。所获得的复合材料通过X射线粉末衍射，透射电子显微镜和UV-vis光谱进行了表征，证明存在8-20 nm球形银纳米颗粒均匀分布并生长在二氧化硅表面。然后将CAB-O-SIL-Ag用作填料，通过流延法和连续凝胶法制备藻酸盐膜。制备具有两种不同银浓度的膜。它们显示出良好的水合性能和非常缓慢的银释放。薄膜具有抗微生物和生物膜活性金黄色葡萄球菌和铜绿假单胞菌对人皮肤的角质形成细胞和人的成纤维细胞没有显示细胞毒性。