Cannabis has been shown to be beneficial in the treatment of pain and inflammatory diseases. The biological effect of cannabis is mainly attributed to two major cannabinoids, tetrahydrocannabinol and cannabidiol. In the majority of studies to-date, a purified tetrahydrocannabinol and cannabidiol alone or in combination have been extensively examined in many studies for the treatment of numerous disorders including pain and inflammation. However, few studies have investigated the biological benefits of full-spectrum cannabis plant extract. Given that cannabis is known to generate a large number of cannabinoids along with numerous other biologically relevant products including terpenes, studies involving purified tetrahydrocannabinol and/or cannabidiol do not consider the potential biological benefits of the full-spectrum cannabis extracts. This may be especially true in the case of cannabis as a potential treatment of pain and inflammation. Herein, we review the pre-clinical physiological and molecular mechanisms in biological systems that are affected by cannabis.

中文翻译：

---

支撑全光谱大麻提取物在治疗神经性疼痛和炎症中的生物学益处的分子机制。

大麻在治疗疼痛和炎性疾病方面被证明是有益的。大麻的生物学效应主要归因于两种主要的大麻素，四氢大麻酚和大麻二酚。迄今为止，在大多数研究中，单独或组合使用纯化的四氢大麻酚和大麻二酚已在许多研究中广泛检查，以治疗包括疼痛和炎症在内的多种疾病。但是，很少有研究调查全光谱大麻植物提取物的生物学益处。鉴于已知大麻会产生大量大麻素以及包括萜烯在内的许多其他生物学相关产品，因此涉及纯化四氢大麻酚和/或大麻二酚的研究并未考虑全光谱大麻提取物的潜在生物学益处。在大麻作为疼痛和发炎的潜在治疗方法的情况下尤其如此。在本文中，我们回顾了受大麻影响的生物系统的临床前生理和分子机制。