Microbial production of medium-chain fatty acids (MCFAs) is challenging, as they are rare metabolites and toxic to cells. Recently, Zhu et al. performed multidimensional engineering in Saccharomyces cerevisiae, including engineering fatty acid synthases and improving cellular tolerance to MCFAs, to build an efficient MCFA cell factory.

中文翻译：

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用于构建高效细胞工厂的多维代谢工程。

中链脂肪酸 (MCFA) 的微生物生产具有挑战性，因为它们是稀有代谢物并且对细胞有毒。最近，朱等人。在酿酒酵母中进行了多维工程，包括工程化脂肪酸合酶和提高细胞对 MCFA 的耐受性，以构建高效的 MCFA 细胞工厂。