Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents,Journal of Chemical & Engineering Data

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Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-03-18 , DOI: 10.1021/acs.jced.0c00025
Mengmeng Liu ₁ , Shui Wang ₁ , Chao Qu ₂ , Zhichao Zhang ₁ , Yixin Qu ₁

Affiliation

In this work, the solubility of bezafibrate in 16 pure solvents including 9 alcohols (methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, 1-pentanol, and iso-pentanol), 4 alkyl acetate (ethyl acetate, n-propyl acetate, n-butyl acetate, and methyl propionate), 2 ketones (methyl ethyl ketone and cyclohexanone) and one nitrile (acetonitrile) and in binary mixed solvents (methanol + acetonitrile) at temperature of 283.15–323.15 K was determined. The solubility of bezafibrate in pure solvents was simulated using modified Apelblat, Van’t Hoff, Wilson, and NRTL model. That in binary mixed solvents was simulated using the modified Apelblat and Apelblat–Jouyban–Acree model. The thermodynamic mixing properties (Δ_mixG, Δ_mixH, Δ_mixS, γ₁^∞, and H₁^E,∞) of the bezafibrate-pure solvent systems were evaluated based on the solubility data and Wilson model.

中文翻译：

苯扎贝特在纯和二元混合溶剂中的溶解度测定和热力学性质

在这项工作中，苯扎贝特在16种纯溶剂中的溶解度包括16种纯醇（甲醇，乙醇，正丙醇，异丙醇，正丁醇，异丁醇，仲丁醇，1-戊醇和异戊醇）， 4乙酸烷基酯（乙酸乙酯，乙酸正丙酯，正乙酸丁酯和丙酸甲酯），2种酮（甲乙酮和环己酮）和一种腈（乙腈）以及在二元混合溶剂（甲醇+乙腈）中测定的温度为283.15–323.15K。使用改良的Apelblat，Van't Hoff，Wilson和NRTL模型模拟苯扎贝特在纯溶剂中的溶解度。使用改良的Apelblat和Apelblat–Jouyban–Acree模型对二元混合溶剂中的溶剂进行模拟。热力学的混合性能（Δ_混合ģ，Δ_混合ħ，Δ_混合小号，γ ₁^∞，和ħ ₁^E，∞基于溶解度数据和Wilson模型苯扎贝特纯溶剂系统）进行了评价。

更新日期：2020-04-24

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