Mechanically and Electrically Enhanced Polyurethane-poly(3,4-ethylenedioxythiophene) Conductive Foams with Aligned Pore Structures Promote MC3T3-E1 Cell Growth and Proliferation,ACS Applied Polymer Materials

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Mechanically and Electrically Enhanced Polyurethane-poly(3,4-ethylenedioxythiophene) Conductive Foams with Aligned Pore Structures Promote MC3T3-E1 Cell Growth and Proliferation
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-03-18 , DOI: 10.1021/acsapm.9b01166
Jin Seul Park ₁ , Hoe Jin Kang ₂ , Byong-Taek Lee ₂ , Jong Seob Choi ₃ , Jin-Heong Yim ₁

Affiliation

Polyurethanes are of great interest in tissue engineering because of their tunable mechanical and nontoxic properties. Various fabrication techniques have been adapted to design polyurethane scaffolds that meet the needs of specific purposes. In this study, 3D flexible conductive polyurethane foam (PUF) was fabricated using a sequential procedure utilizing gas foaming and vapor phase polymerization methods. The conductive PUF produced shows an internal pore architecture allowing nutrients to be circulated. Its mechanical properties and interconnected pore shapes can also be tailored by either changing the mixing ratio of polytetramethylene ether glycol and polymeric methylene diphenyl diisocyanate or compressive pressure. In addition, the introduction of poly(3,4-ethylenedioxythiophene) (PEDOT) to impart electrical properties to the PUF results in long-term reliability in electrical and mechanical properties. In order to make aligned pore structures in the PUF, compressive pressures were applied during fabrication. Bending tests and resistance variation measurements of PUF-PEDOT and PUF-P (pressed)-PEDOT were conducted and compared. PUF-P-PEDOT demonstrated lower electrical resistance than PUF-PEDOT. Moreover, no significant variation in resistance occurred even after 5000 repeated bending experiments, meaning that PUF-P-PEDOT is sufficiently stable for flexible strain sensor applications. A water-soluble tetrazolium salt assay for the evaluation of biocompatibility was also conducted by using MC3T3-E1 cell culture. Aligned and conductive PUF structures exhibit enhanced cell growth and proliferation at day 7.

中文翻译：

机械和电气增强的具有对齐孔结构的聚氨酯-聚（3,4-乙撑二氧噻吩）导电泡沫可促进MC3T3-E1细胞的生长和增殖

聚氨酯由于其可调的机械和无毒特性而在组织工程中引起了极大的兴趣。已经采用了各种制造技术来设计满足特定目的需求的聚氨酯支架。在本研究中，使用气相发泡和气相聚合方法的顺序过程制造了3D柔性导电聚氨酯泡沫（PUF）。产生的导电PUF具有内部孔结构，可以使营养物质循环。也可以通过改变聚四亚甲基醚二醇与聚合亚甲基二苯基二异氰酸酯的混合比或压缩压力来调整其机械性能和相互连通的孔形状。另外，引入了poly（3，赋予PUF电性能的4-乙撑二氧噻吩（PEDOT）在电气和机械性能方面具有长期可靠性。为了在PUF中形成对齐的孔结构，在制造过程中施加了压缩压力。进行了PUF-PEDOT和PUF-P（压制）-PEDOT的弯曲测试和电阻变化测量。PUF-P-PEDOT的电阻低于PUF-PEDOT。此外，即使经过5000次重复弯曲实验，电阻也没有发生明显变化，这意味着PUF-P-PEDOT对于挠性应变传感器的应用而言足够稳定。还通过使用MC3T3-E1细胞培养进行了水溶性四唑盐分析，以评估生物相容性。

更新日期：2020-04-23

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