An alternative approach for the preparation of a core-shell bimetallic central metal-organic framework as a hydrophilic interaction liquid chromatography stationary phase.,Analyst

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An alternative approach for the preparation of a core-shell bimetallic central metal-organic framework as a hydrophilic interaction liquid chromatography stationary phase.
Analyst ( IF 3.6 ) Pub Date : 2020-03-18 , DOI: 10.1039/d0an00304b
Tiantian Si ₁ , Licheng Wang ₂ , Xiaofeng Lu ₂ , Xiaojing Liang ₂ , Shuai Wang ₂ , Yong Guo ₂

Affiliation

A new type of core–shell composite material was prepared and applied as a hydrophilic interaction liquid chromatography (HILIC) stationary phase. In this work, silica spheres were first modified with a bimetallic central metal–organic framework (ZnCoMOF) by a new strategy of static self-assembled in situ growth. This strategy was beneficial for increasing the electrostatic interaction between the MOF ligand and silica via introducing a sodium dodecylbenzenesulfonate (SDBS) group. The ZnCoMOF@silica stationary phase was characterized and evaluated in comparison with amino-modified and bare silica columns in terms of various polar analytes including eight nucleosides and nucleobases, seven carbohydrates, and multiple sulfonamides and antibiotics. The effects of organic solvent concentration, water content, the concentration of the salt and the pH of the buffer solution on the retention time were studied, which demonstrated the typical retention behavior of HILIC on the ZnCoMOF@silica column. Compared with most reported MOF-based stationary phases, the new composite material showed excellent hydrophilic properties and separation efficiency for various polar analytes. Moreover, the obtained stationary phase showed good reproducibility and stability. The relative standard deviation (RSD) of the retention time for repeatability was found to range from 0.1% to 0.6%, and the RSD of the retention time for stability was found to range from 0.3% to 0.7%. Furthermore, the column batch-to-batch reproducibility showed excellent preparation reproducibility, which few reported in most previous MOF@silica composite materials. This specific preparation method offers an easy and novel way to manipulate the amount of MOF particles on silica, which extends a universal way to produce various MOF@silica stationary phases by the method of static self-assembled in situ growth.

中文翻译：

制备核-壳双金属中心金属-有机骨架作为亲水相互作用液相色谱固定相的另一种方法。

制备了一种新型的核-壳复合材料，并将其用作亲水相互作用液相色谱（HILIC）固定相。在这项工作中，首先采用静态自组装原位生长的新策略，使用双金属中心金属-有机骨架（ZnCoMOF）修饰了二氧化硅球。这种策略是为MOF配体与二氧化硅之间增加的静电相互作用有利经由引入十二烷基苯磺酸钠（SDBS）基团。ZnCoMOF @ silica固定相的特性和与氨基修饰的和裸露的硅胶柱相比，在各种极性分析物（包括八个核苷和核碱基，七个碳水化合物以及多种磺酰胺和抗生素）中进行了表征和评估。研究了有机溶剂浓度，水含量，盐浓度和缓冲溶液的pH值对保留时间的影响，证明了HILIC在ZnCoMOFF硅胶柱上的典型保留行为。与大多数报道的基于MOF的固定相相比，这种新型复合材料对各种极性分析物均具有出色的亲水性和分离效率。此外，所获得的固定相显示出良好的再现性和稳定性。发现重复性的保留时间的相对标准偏差（RSD）为0.1％至0.6％，稳定性的保留时间的RSD为0.3％至0.7％。此外，色谱柱的批间重现性显示了出色的制备重现性，在大多数以前的MOF @二氧化硅复合材料中几乎没有报道。这种特定的制备方法提供了一种简单新颖的方法来控制二氧化硅上的MOF颗粒数量，从而扩展了通过静态自组装方法生产各种MOF @二氧化硅固定相的通用方法色谱柱的批间重现性显示出优异的制备重现性，在大多数以前的MOF @二氧化硅复合材料中很少报道。这种特定的制备方法提供了一种简便新颖的方法来控制二氧化硅上的MOF颗粒数量，从而扩展了通过静态自组装方法生产各种MOF @二氧化硅固定相的通用方法色谱柱的批间重现性显示出优异的制备重现性，在大多数以前的MOF @二氧化硅复合材料中很少报道。这种特定的制备方法提供了一种简单新颖的方法来控制二氧化硅上的MOF颗粒的数量，从而扩展了通过静态自组装方法生产各种MOF @二氧化硅固定相的通用方法原位生长。

更新日期：2020-03-18

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