Many studies showed that anatomical connectivity supports both anatomical and functional hierarchies that span across the primary and association cortices in the cerebral cortex. Even though a structure–function relationship has been indicated to uncouple in the association cortex, it is still unknown whether anatomical connectivity can predict functional activations to the same degree throughout the cortex, and it remains unclear whether a hierarchy of this connectivity–function relationship (CFR) exists across the human cortex. We first addressed whether anatomical connectivity could be used to predict functional activations across different functional domains using multilinear regression models. Then, we characterized the CFR by predicting activity from anatomical connectivity throughout the cortex. We found that there is a hierarchy of CFR between sensory–motor and association cortices. Moreover, this CFR hierarchy was correlated to the functional and anatomical hierarchies, respectively, reflected in functional flexibility and the myelin map. Our results suggest a shared hierarchical mechanism in the cortex, a finding which provides important insights into the anatomical and functional organizations of the human brain.

中文翻译：

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通过预测跨功能域的活动揭示了人类皮层的连接-功能关系的层次结构。

许多研究表明，解剖学连通性支持跨越大脑皮层初级和关联皮质的解剖学和功能层次结构。尽管结构-功能关系已被证明在关联皮层中解耦，但解剖学连接是否可以预测整个皮层的功能激活程度仍然未知，并且还不清楚这种连接-功能关系的层次结构。 CFR) 存在于整个人类皮层。我们首先讨论了解剖连接是否可用于使用多元线性回归模型预测不同功能域的功能激活。然后，我们通过预测整个皮层解剖连接的活动来表征 CFR。我们发现感觉运动和关联皮质之间存在 CFR 等级。此外，该 CFR 层次结构分别与功能和解剖层次结构相关，反映在功能灵活性和髓磷脂图上。我们的研究结果表明皮层中存在共享的分层机制，这一发现为人类大脑的解剖和功能组织提供了重要的见解。