Recent clinical and neurobehavioral evidence suggests cerebellar dysfunction in schizophrenia (SZ). We used the prism adaptation motor task (PAT) to probe specific cerebellar circuits in the disorder. PAT requires cerebellum-dependent motor adaptation, perceptual remapping, and strategic control. A failure to engage in early corrective processes may indicate impairment within either the cerebellum or regions contributing to strategic components, such as the parietal lobe, while an inability to develop and retain a visuomotor shift with time strongly suggests cerebellar impairment. Thirty-one individuals with SZ and 31 individuals without a history of psychological disorders completed PAT. Subjects reached to a target before, during, and following prism exposure, while their movements were recorded using motion-sensing technology. The SZ group performed worse on conditions consisting of adaptation, post-adaptation, aftereffects, and reorientation, thereby demonstrating a failure to adapt to the same degree as healthy controls. SZ performance remained impaired even with visual feedback and did not differ from controls at baseline, suggesting the observed deficit is specific to adaptation. Results indicate that sensorimotor adaptation is impaired in SZ and implicate disturbances in cerebellar circuits.

中文翻译：

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精神分裂症的棱镜适应缺陷


最近的临床和神经行为证据表明精神分裂症（SZ）存在小脑功能障碍。我们使用棱镜适应运动任务（PAT）来探测该疾病中的特定小脑回路。 PAT 需要小脑依赖性运动适应、知觉重新映射和策略控制。未能参与早期纠正过程可能表明小脑或负责战略组成部分（例如顶叶）的区域受损，而无法随着时间的推移发展和保持视觉运动转变强烈表明小脑受损。 31 名精神分裂症患者和 31 名没有心理障碍史的患者完成了 PAT。受试者在棱镜暴露之前、期间和之后到达目标，同时使用运动传感技术记录他们的动作。 SZ 组在适应、适应后、后遗症和重新定向等条件上表现较差，从而表明未能达到与健康对照组相同的适应程度。即使有视觉反馈，SZ 表现仍然受损，并且与基线时的对照组没有差异，这表明观察到的缺陷是适应所特有的。结果表明，SZ 中的感觉运动适应受损，并暗示小脑回路受到干扰。