Piwi proteins are aberrantly induced in human tumours, but their function in cancer has been poorly understood. A study now shows that in the absence of piRNA loading, human PIWIL1 promotes pancreatic cancer metastasis by acting as a co-activator of the anaphase-promoting complex/cyclosome (APC/C) to degrade the cell-adhesion protein Pinin.

中文翻译：

---

piRNA未结合的PIWIL1促进转移

Piwi蛋白是在人类肿瘤中异常诱导的，但是人们对它们在癌症中的功能却知之甚少。现在的一项研究表明，在没有piRNA负载的情况下，人PIWIL1通过充当促后期复合物/环体（APC / C）的共激活物来降解细胞粘附蛋白Pinin，从而促进胰腺癌转移。