Abstract

A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes, delivering structurally diverse chiral β-branched a-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo- and enantioselectivities.

中文翻译：

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钯催化1,4-二烯和甘氨酸席夫碱的不对称烯丙基CH烷基化

摘要

通过手性钯-亚磷酰胺催化已经建立了具有甘氨酸席夫碱的1，4-二烯的高度区域和对映选择性烯丙基CH烷基化。该反应可在温和条件下进行，并能耐受各种1,4-二烯，以中等至高收率和高水平的区域，Z / E-，非对映体的形式提供结构多样的手性β-支链α-氨基酸替代物-和对映选择性。