Abstract This work studied the in vitro angiogenic response of human umbilical vein endothelial cells on the copper-doped titanium nitride (TiCuN) coating, which has been proved to own good antibacterial ability and excellent corrosion resistance as well as wear resistance. It was found that TiCuN coating had no cytotoxic effect and promoted the early cell proliferation, furthermore it significantly promoted the mRNA expressions of eNOS and VEGF, also obviously enhanced the cell migration and tube formation compared with TiN coating, which indicated that TiCuN coating can improve the angiogenesis ability of biomaterials and would gain new opportunities for the applications in orthopedic and cardiovascular fields.

中文翻译：

---

铜掺杂氮化钛涂层对血管生成的影响

摘要 本工作研究了人脐静脉内皮细胞对掺铜氮化钛（TiCuN）涂层的体外血管生成反应，该涂层已被证明具有良好的抗菌能力和优异的耐腐蚀性能和耐磨性。发现TiCuN涂层无细胞毒作用，促进早期细胞增殖，显着促进eNOS和VEGF的mRNA表达，与TiN涂层相比，也明显增强细胞迁移和管形成，表明TiCuN涂层可以改善生物材料的血管生成能力，将为骨科和心血管领域的应用提供新的机会。