Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

中文翻译：

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肾癌中的脂质：女王蜂成为目标？

透明细胞肾细胞癌（ccRCC）是最常见的肾癌亚型，其特征在于脂质存储表型。我们发现，肉碱棕榈酰转移酶1A（CPT1A）是线粒体脂肪酸（FA）转运的限速酶，可被缺氧诱导因子（HIF）抑制，从而减少FA氧化（FAO）。改变脂质代谢可能是ccRCC的新治疗途径。