Semi-batch precipitation of sparingly soluble materials is an important unit operation in the chemical or pharmaceutical industry. Unfortunately, dynamic process flowsheet simulation of this unit operation has not been possible yet, as existing models for stirred-tank reactors are far too computationally intensive.

In this work, we present a real-time capable semi-batch model for precipitation process flowsheet simulation. Its outstanding numerical performance is based on a frequently triggered approximation of the steady-state reaction zone in the tank. We validate the model by barium sulfate precipitation experiments and investigate the semi-batch specific process dynamics. Furthermore, the model is applied to simulation setups with dynamic boundaries and process parameters to characterize the influence of dynamic process parameters on the product particle size distribution (PSD). It is shown that dynamic process parameters can influence the final PSD heavily. The model will, therefore, be a useful tool for future application in dynamic process optimization.

难溶物质的半间歇沉淀是化学或制药工业中的重要单元操作。不幸的是，由于搅拌釜反应器的现有模型计算量太大，因此尚未能够对该单元操作进行动态过程流程图模拟。

在这项工作中，我们提出了一种实时有效的半批处理模型，用于降水过程模拟。其出色的数值性能基于罐中稳态反应区域的频繁触发近似值。我们通过硫酸钡沉淀实验验证了该模型，并研究了半批特定工艺动力学。此外，该模型还应用于具有动态边界和过程参数的仿真设置，以表征动态过程参数对产品粒度分布（PSD）的影响。结果表明，动态过程参数会严重影响最终的PSD。因此，该模型将成为将来在动态过程优化中应用的有用工具。