Implant-related infection and early bone integration are the main risk factors of implants for long-term service, to overcome these difficulties, SLA-TiCu surface was prepared by sandblasting and large-grits etching (SLA) treatment on a novel antibacterial titanium-copper alloy (TiCu), which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants. Effects of SLA-TiCu surface on the adhesion, proliferation, apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen (Staphylococcus aureus) were studied. Compared to the following surfaces: sandblasting and large-grits etched pure titanium (SLA-Ti), mechanically ground pure titanium and TiCu alloy (M-Ti and M-TiCu), these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions (alkaline phosphates (ALP), collagen type I (COL I), Runt-related transcription factor 2 (RUN × 2), and osteopontin (OPN)). Moreover, SLA-TiCu surface could maintain a sustainable release of Cu²⁺ ions and effectively inhibited the viability of bacteria. This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity, making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants.

植入物相关的感染和早期骨整合是长期使用的植入物的主要危险因素，为了克服这些困难，通过喷砂和大网格蚀刻（SLA）处理在新型抗菌钛铜上制备了SLA-TiCu表面合金（TiCu），这是对钛基植入物采用微米/亚微米分级结构的最流行表面处理。SLA-TiCu表面对MC3T3-E1细胞黏附，增殖，凋亡和分化的影响以及对常见骨科病原体（金黄色葡萄球菌）的抗菌活性）进行了研究。与以下表面相比：喷砂和大磨蚀的纯钛（SLA-Ti），机械研磨的纯钛和TiCu合金（M-Ti和M-TiCu），这些结果表明SLA-TiCu表面显着增强了骨骼-相关的基因表达（碱性磷酸酶（ALP），I型胶原蛋白（COL I），矮子相关转录因子2（RUN×2）和骨桥蛋白（OPN））。此外，SLA-TiCu表面可以维持Cu ²⁺离子的可持续释放，并有效抑制细菌的生存能力。这项研究表明，SLA-TiCu表面具有改善成骨能力和抗菌活性的多功能特性，使其有望作为一种新型的植入物用于硬组织修复，例如整形外科和牙科植入物。