Successful passive transfer of antibodies in neonatal calves can be achieved by feeding an adequate quantity and quality of maternal colostrum (MC) or colostrum replacer (CR). An alternative could be feeding low-quality maternal colostrum (LMC) with added IgG from a CR. The objective of this study was to determine if a commercial whey-based CR product containing low levels of casein (Premolac PLUS Bovine IgG; Zinpro Corporation, Eden Prairie, MN) fed to replace MC or supplement LMC could lead to adequate serum IgG levels and apparent efficiency of absorption (AEA) in neonatal dairy calves. Holstein calves (n = 20 per treatment) were separated from their dam after birth and randomly assigned to be fed 3.79 L of MC (106 g/L of IgG; 401 g of IgG fed), LMC (30 g/L IgG) supplemented with CR (41 g/L IgG; 154 g of IgG total fed; LMC-CR), or 1.3 L of 1 of 2 levels of CR (110 or 150 g of IgG fed; CR-110 or CR-150) within 1.5 h of birth. Colostrum was obtained from the first (MC) or second and third milkings (LMC) of cows from Pennsylvania State University dairy and pooled by source into large batches. Blood samples were taken from calves before colostrum feeding and 24 h after birth and were analyzed for serum total protein, total IgG, hematocrit, and Brix percentage. Calves fed MC had higher 24-h IgG values (means ± SEM) than calves fed LMC-CR (27.04 ± 1.07 vs. 22.33 ± 1.08 mg/mL, respectively). Feeding 150 g of IgG from CR led to higher 24-h serum IgG values than feeding 110 g of IgG (16.90 ± 1.09 vs. 12.79 ± 1.08 mg/mL). Serum IgG levels were different between the CR-fed calves and the calves fed LMC-CR and MC, but all had average values >10 mg/mL IgG. Calves fed LMC-CR had greater AEA than calves fed MC (54.58 ± 2.39 vs. 24.38 ± 2.36%, respectively). Among calves fed CR-110 or CR-150, AEA did not differ. Serum total protein and Brix percentage had strong correlations with actual IgG values across the entire study. We found no differences in average daily gain or health variables measured, and no differences in final hip width, withers height, or body weight for calves fed MC, LMC-CR, CR-150, or CR-110. These results indicate that CR can be fed successfully as an alternative to MC or as a supplement to colostrum with low IgG.

中文翻译：

---

牛初乳，商业乳清替代初乳或补充初乳的小牛的免疫球蛋白G吸收的比较。

可以通过喂养足够数量和质量的母初乳（MC）或初乳替代品（CR）来实现新生牛犊中抗体的成功被动转移。一种替代方法是用CR补充的IgG喂养低质量的母体初乳（LMC）。这项研究的目的是确定喂养酪蛋白含量较低的商业乳清基CR产品（Premolac PLUS牛IgG； Zinpro Corporation，Eden Prairie，MN）是否可以替代MC或补充LMC，从而导致血清IgG含量充足和新生乳牛犊的表观吸收效率（AEA）。荷斯坦犊牛（每处理n = 20）在出生后与大坝分离，随机分配喂食3.79 L MC（106 g / L IgG； 401 g IgG），补充LMC（30 g / L IgG） CR（41 g / L IgG;总共154 g IgG; LMC-CR）或1。出生后1.5小时内2份CR中的1份中含有3 L（110或150 g IgG； CR-110或CR-150）。初乳是从宾夕法尼亚州立大学奶牛的第一次（MC）或第二次和第三次挤奶（LMC）中获得的，并按来源分成大批。在初乳喂养前和出生后24小时从小牛取血，并分析其血清总蛋白，总IgG，血细胞比容和白利糖度。饲喂MC的犊牛比饲喂LMC-CR的犊牛具有更高的24小时IgG值（平均值±SEM）（分别为27.04±1.07和22.33±1.08 mg / mL）。从CR饲喂150 g IgG比饲喂110 g IgG导致更高的24小时血清IgG值（16.90±1.09对12.79±1.08 mg / mL）。饲喂CR的犊牛和饲喂LMC-CR和MC的犊牛的血清IgG水平有所不同，但均具有> 10 mg / mL IgG的平均值。饲喂LMC-CR的犊牛的AEA高于饲喂MC的犊牛（分别为54.58±2.39和24.38±2.36％）。在饲喂CR-110或CR-150的犊牛中，AEA没有差异。在整个研究中，血清总蛋白和白利糖度百分比与实际IgG值具有很强的相关性。我们发现，饲喂MC，LMC-CR，CR-150或CR-110的小牛的平均日增重或健康变量没有差异，最终臀部宽度，肩高或体重也没有差异。这些结果表明，CR可以作为MC的替代品或低IgG初乳的补充品而成功饲喂。我们发现，饲喂MC，LMC-CR，CR-150或CR-110的小牛的平均日增重或健康变量没有差异，最终臀部宽度，肩高或体重也没有差异。这些结果表明，CR可以作为MC的替代品或低IgG初乳的补充品而成功饲喂。我们发现，饲喂MC，LMC-CR，CR-150或CR-110的小牛的平均日增重或健康变量没有差异，最终臀部宽度，肩高或体重也没有差异。这些结果表明，CR可以作为MC的替代品或低IgG初乳的补充品而成功饲喂。