Research over the past few decades has shed light on the mechanisms underlying the link between circadian disruption and the development of metabolic diseases such as obesity, type 2 diabetes, and cancer. However, how the clock network interacts with tissue-specificnutrient-sensing pathways during conditions of nutrient stress or pathological states remains incompletely understood. Recent work has demonstrated that the circadian clock can 'reprogram' the transcriptome to control distinct sets of genes during altered nutrient conditions, such as high fat diet, aging, and exercise. In this review, I discuss connections between circadian clock transcription factors and the oxygen- and nutrient-responsivehypoxia-inducible factor (HIF) pathway. I highlight recently uncovered mechanistic insights underlying these pathway interactions and address potential implications for the role of circadian disruption in metabolic diseases.

中文翻译：

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昼夜节律 - HIF 串扰的代谢影响


过去几十年的研究揭示了昼夜节律紊乱与肥胖、2 型糖尿病和癌症等代谢疾病发展之间联系的潜在机制。然而，在营养应激或病理状态下，时钟网络如何与组织特异性营养传感途径相互作用仍不完全清楚。最近的研究表明，生物钟可以“重新编程”转录组，以在营养条件改变（例如高脂肪饮食、衰老和运动）期间控制不同的基因组。在这篇综述中，我讨论了生物钟转录因子与氧和营养响应性缺氧诱导因子 (HIF) 通路之间的联系。我重点介绍了最近发现的这些通路相互作用背后的机制见解，并讨论了昼夜节律破坏在代谢疾病中的作用的潜在影响。