The superfamily of cytochrome P450 monooxygenases (P450s) is widespread in all kingdoms of life. Functionally versatile P450s are extensively involved in diverse anabolic and catabolic processes. P450s require electrons to be transferred by redox partners (RPs) for O2 activation and substrate monooxygenation. Unlike monotonic eukaryotic cytochrome P450 reductases, bacterial RP systems are more diverse and complicated. Recent studies have demonstrated that the type, the amount, the combination, and the mode of action of bacterial RPs can affect not only the catalytic rate and product distribution but also the type and selectivity of P450 reactions. These results are leading to a novel opinion that RPs not only function as auxiliary electron transfer proteins but are also important P450 function modulators.

中文翻译：

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氧化还原伙伴：细菌P450酶的功能调节剂。

细胞色素P450单加氧酶（P450s）的超家族在生活的各个王国中都很普遍。功能多样的P450广泛参与各种合成代谢和分解代谢过程。P450要求电子通过氧化还原伙伴（RP）转移，以激活O2和进行底物单加氧。与单调的真核细胞色素P450还原酶不同，细菌RP系统更加多样化和复杂。最近的研究表明，细菌RP的类型，数量，组合和作用方式不仅会影响催化速率和产物分布，还会影响P450反应的类型和选择性。这些结果导致了新颖的观点，即RPs不仅起辅助电子转移蛋白的作用，而且还是重要的P450功能调节剂。