Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) identifies patients with acute onset of obsessive-compulsive and tic disorders. The objective of this study was to evaluate serum NOX2 levels, as well as 8-iso-prostaglandin F2α (8-iso-PGF2α) and lipopolysaccharide (LPS) of PANDAS patients. In this study we wanted to compare serum levels of soluble NOX2-dp (sNOX-2-dp), iso-PGF2α and LPS in 60 consecutive subjects, including 30 children affected by PANDAS and 30 controls (CT) matched for age and gender. Serum zonulin was used as intestinal permeability assay. Compared with CT, PANDAS children had increased serum levels of sNOX-2-dp, 8-iso-PGF2α and LPS. Bivariate analysis showed that serum sNOX2-dp was significantly correlated with LPS (Rs = 0.359; p = 0.005), zonulin (Rs = 0.444; p < 0.001) and 8-iso-PGF2α (Rs = 0.704; p < 0.001). Serum LPS significantly correlated with zonulin (Rs = 0.610; p < 0.001), and 8-iso-PGF2α (Rs = 0.591; p = 0.001). Finally, a multiple linear regression analysis showed that serum 8-iso-PGF2α and zonulin were the only independent variables associated with sNOX2-dp (R2 = 68%). This study shows that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be involved in the process of neuroinflammation.

中文翻译：

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患儿与链球菌感染有关的小儿自身免疫性神经精神疾病的患儿的氧化应激和肠源性脂多糖

与链球菌感染综合征（PANDAS）相关的小儿自身免疫性神经精神疾病可识别患有强迫症和抽动症的急性发作患者。这项研究的目的是评估PANDAS患者的血清NOX2水平，8-异前列腺素F2α（8-异-PGF2α）和脂多糖（LPS）。在这项研究中，我们想比较60例连续受试者（包括30名受PANDAS影响的儿童和30名年龄和性别相符的对照）的可溶性NOX2-dp（sNOX-2-dp），iso-PGF2α和LPS的血清水平。血清zonulin用作肠通透性测定。与CT相比，PANDAS儿童的血清sNOX-2-dp，8-iso-PGF2α和LPS升高。双变量分析显示血清sNOX2-dp与LPS（Rs = 0.359; p = 0.005），连蛋白（Rs = 0.444; p <0）显着相关。001）和8-iso-PGF2α（Rs = 0.704; p <0.001）。血清LPS与zonulin（Rs = 0.610; p <0.001）和8-iso-PGF2α（Rs = 0.591; p = 0.001）显着相关。最后，多元线性回归分析显示，血清8-iso-PGF2α和zonulin是与sNOX2-dp相关的唯一独立变量（R2 = 68％）。这项研究表明，受PANDAS影响的儿童的sNOX2-dp，异前列腺素和LPS的循环水平较高，可能参与神经炎症过程。