Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka. This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women. Methods Cross-sectional study was conducted at the Endocrine Unit, Teaching Hospital Jaffna from January to December 2018. During this period 105 postmenopausal women who registered for bone density assessment were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nurses and total 25-Hydroxy Vitamin D level (25(OH)-Vit D) was measured by competitive immunoassay with enhanced chemiluminiscence technique, levels were categorized and analysis was done using SPSS 26. Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean total 25(OH)-Vit D was 27.5 (range11.7-52.5 ng/mL). 25(OH)-Vit D levels were adequate in only 36.2% (95%CI: 27-45), 44% had insufficient levels and deficiency was present in 19% (95%CI: 12-27) of postmenopausal women. Among total study participants 20% were vegetarian, 53, 76.2 and 64.8% were consuming milk, fish and egg respectively and 71.4% reported adequate level of sun exposure (> 30 min/day). Commonly reported vitamin D deficiency symptoms include paraesthesia (57.1%), bone-pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%). Nevertheless, comparison of musculoskeletal symptoms between group with sufficient level and group with insufficient and deficient level showed no significant difference (P > 0.05). Among 71 participants (66.7%) who completed bone density assessment, 38% (95%CI: 27-49) showed osteoporosis. Vertebral Z score showed a significant correlation with 25(OH)-Vit D level (r-0.252, P-0.03). Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to consider vitamin D supplementation when initiating treatment for osteoporosis. Hence, Vitamin D testing is desirable in decision making to treat or not to treat.

中文翻译：

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绝经后骨质疏松妇女的维生素 D 状况：来自斯里兰卡北部的基于医院的横断面研究。

背景维生素 D 缺乏症在绝经后妇女中很常见，治疗维生素 D 缺乏症对于预防骨质疏松症患者跌倒和骨折非常重要。很少有研究检查斯里兰卡普通人群中维生素 D 缺乏症的患病率，但迄今为止尚未对斯里兰卡的绝经后骨质疏松症妇女进行研究。这是斯里兰卡第一项评估绝经后妇女血清维生素 D 水平的此类研究。方法于 2018 年 1 月至 2018 年 12 月在贾夫纳教学医院内分泌科进行横断面研究。在此期间，招募了 105 名登记进行骨密度评估的绝经后妇女参与研究。数据收集由研究人员完成，注册护士从每个参与者身上采集血液样本，并通过竞争性免疫测定和增强化学发光技术测量总 25-羟基维生素 D 水平 (25(OH)-Vit D)，对水平进行分类并进行分析。使用 SPSS 26 完成。结果 105 名绝经后妇女的平均年龄为 67.7 岁，最小 33 岁，最大 84 岁。平均总 25(OH)-Vit D 为 27.5（范围 11.7-52.5 ng/mL）。25(OH)-Vit D 水平仅在 36.2% (95%CI: 27-45) 中充足，44% 水平不足，19% (95%CI: 12-27) 的绝经后妇女存在缺乏。在所有研究参与者中，20% 是素食者，53%、76.2% 和 64.8% 分别食用牛奶、鱼和鸡蛋，71.4% 的人报告有足够的日晒水平（> 30 分钟/天）。常见的维生素 D 缺乏症状包括感觉异常（57.1%）、骨痛（55.2%）、易疲劳（54.3%）、不适（51.4%）、肌肉痉挛（43.8%）和近端肌病（40.0%）。然而，水平充足组与水平不足组和不足组的肌肉骨骼症状比较差异无统计学意义（P > 0.05）。在完成骨密度评估的 71 名参与者 (66.7%) 中，38% (95%CI: 27-49) 显示骨质疏松症。椎体 Z 评分与 25(OH)-Vit D 水平显着相关（r-0.252，P-0.03）。结论 初步诊断为骨质疏松的绝经后妇女维生素 D 缺乏症的患病率较高。在开始治疗骨质疏松症时，必须考虑补充维生素 D。因此，