当前位置：
X-MOL 学术
›
ChemPlusChem
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Drug Release from Polymer Thin Films and Gel Pellets: Insights from Programmed Microplate Electroanalysis.
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-04-01 , DOI: 10.1002/cplu.202000129 Adrian Ruff 1 , Wajee Jaikaew 2 , Panida Khunkaewla 2 , Wolfgang Schuhmann 1 , Albert Schulte 3
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-04-01 , DOI: 10.1002/cplu.202000129 Adrian Ruff 1 , Wajee Jaikaew 2 , Panida Khunkaewla 2 , Wolfgang Schuhmann 1 , Albert Schulte 3
Affiliation
|
Robotic electroanalysis in 24‐well microplates was used to determine Paracetamol (PCT) release from thin films of chitosan and two pH‐sensitive synthetic polymers as well as blends of the polymers with each other and with agarose. Square‐wave voltammograms were recorded automatically in a potential window of 0.35 V–0.85 V vs. Ag/AgCl/0.1 M KCl and their evaluation revealed time‐dependent PCT release into acidic and basic media. Comparison of the release profiles showed that pure chitosan layers released PCT quickly in a single‐phase process while liberation from synthetic polymer thin films was slower with a sigmoidal shape at pH 1.2 and pH 8.0 with a maximum release of PCT after approximately 150 and 140 min, respectively. The release profile from thicker agarose films was between those of the thin films. Agarose blended with chitosan or synthetic polymers formed films with biphasic release behavior. Chitosan linearized the initial section of the release profile in chitosan/polymer blends. The automated procedure for release testing offers the advantage of low‐cost, labor‐effective and error‐free data acquisition. The procedure has been validated as a useful microplate assay option for release profile testing.
中文翻译：
聚合物薄膜和凝胶颗粒中的药物释放：程序化微孔板电分析的见解。
使用24孔微孔板中的机器人电分析法测定乙酰氨基酚（PCT）从壳聚糖和两种pH敏感的合成聚合物薄膜中释放的对乙酰氨基酚（PCT）以及这些聚合物之间以及与琼脂糖的共混物。方波伏安图自动记录在相对于Ag / AgCl / 0.1 M KCl的0.35 V–0.85 V电位窗口中，其评估表明PCT随时间释放到酸性和碱性介质中。释放曲线的比较表明，纯壳聚糖层在单相过程中快速释放PCT，而在pH 1.2和pH 8.0时从合成聚合物薄膜中释放则呈S形，在大约150和140分钟后PCT释放最大。 ， 分别。较厚的琼脂糖薄膜的释放曲线介于薄膜之间。琼脂糖与壳聚糖或合成聚合物混合形成具有双相释放行为的薄膜。壳聚糖线性化了壳聚糖/聚合物共混物中释放曲线的初始部分。自动化的发布测试程序具有低成本，劳动有效且无错误的数据采集的优势。该程序已被验证为用于释放曲线测试的有用的微孔板检测选项。
更新日期：2020-04-22
中文翻译：
聚合物薄膜和凝胶颗粒中的药物释放：程序化微孔板电分析的见解。
使用24孔微孔板中的机器人电分析法测定乙酰氨基酚（PCT）从壳聚糖和两种pH敏感的合成聚合物薄膜中释放的对乙酰氨基酚（PCT）以及这些聚合物之间以及与琼脂糖的共混物。方波伏安图自动记录在相对于Ag / AgCl / 0.1 M KCl的0.35 V–0.85 V电位窗口中，其评估表明PCT随时间释放到酸性和碱性介质中。释放曲线的比较表明，纯壳聚糖层在单相过程中快速释放PCT，而在pH 1.2和pH 8.0时从合成聚合物薄膜中释放则呈S形，在大约150和140分钟后PCT释放最大。 ， 分别。较厚的琼脂糖薄膜的释放曲线介于薄膜之间。琼脂糖与壳聚糖或合成聚合物混合形成具有双相释放行为的薄膜。壳聚糖线性化了壳聚糖/聚合物共混物中释放曲线的初始部分。自动化的发布测试程序具有低成本，劳动有效且无错误的数据采集的优势。该程序已被验证为用于释放曲线测试的有用的微孔板检测选项。
京公网安备 11010802027423号