Conventional and microwave reactions of 1,3‐diaryl‐5,4‐enaminonitrile‐pyrazole derivative with expected antimicrobial and anticancer activities,Journal of Heterocyclic Chemistry

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Conventional and microwave reactions of 1,3‐diaryl‐5,4‐enaminonitrile‐pyrazole derivative with expected antimicrobial and anticancer activities
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-03-17 , DOI: 10.1002/jhet.3946
Kurls E. Anwer ₁ , Galal H. Sayed ₁

Affiliation

The present study illustrates conventional and microwave reactions of 5‐amino‐1,3‐diaryl‐pyrazole‐4‐carbonitrile derivative with phenacyl bromide under different conditions, hydrazine hydrate, hydroxylamine hydrochloride, tetrahydrofuran, phthalic anhydride, and cyanoacetic acid. The product of the latter reaction condensed with hydrazine and cyclohexanone to give the pyrazolotriazepine acetonitrile and cyclohexylidene derivatives. The new cyclohexylidene is used as key intermediate to synthesize some new spiro compounds. The behavior of the starting compound with benzaldehyde, ethylenediamine, phenylenediamine, sodium azide, 1‐amino‐2‐hydroxynaphthalene‐7‐sulphonic acid, diethylmalonate, terephthalaldehyde, acetyl chloride, and acetic anhydride were also investigated. The new compounds structures were established from spectroscopic data. Some of the new pyrazole derivatives showed antibacterial and anticancer activities.

中文翻译：

1,3-二芳基-5,4-烯氨基腈-吡唑衍生物的常规和微波反应具有预期的抗微生物和抗癌活性

本研究说明了在不同条件下，水合肼，盐酸羟胺，四氢呋喃，邻苯二甲酸酐和氰基乙酸在不同条件下5-氨基-1,3-二芳基吡唑-4-腈与苯甲酰溴的常规反应和微波反应。后一反应的产物与肼和环己酮缩合，得到吡唑并三氮杂pine乙腈和环己叉基衍生物。新的环己叉基用作合成某些新螺环化合物的关键中间体。还研究了起始化合物与苯甲醛，乙二胺，苯二胺，叠氮化钠，1-氨基-2-羟基萘-7-磺酸，丙二酸二乙酯，对苯二甲醛，乙酰氯和乙酸酐的行为。从光谱数据建立新的化合物结构。

更新日期：2020-03-17

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