Greener route for microwave enhanced syntheses of bioactive 1,5‐benzodiazepines using heterogeneous calcium ferrite/graphene oxide nanocomposite as a novel and sustainable catalyst,Journal of Heterocyclic Chemistry

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Greener route for microwave enhanced syntheses of bioactive 1,5‐benzodiazepines using heterogeneous calcium ferrite/graphene oxide nanocomposite as a novel and sustainable catalyst
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-03-16 , DOI: 10.1002/jhet.3957
Sharoni Gupta ₁ , Chetna Ameta ₁ , Pinki Bala Punjabi ₁

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In the present paper, a novel and benign protocol for microwave enhanced one pot syntheses of 2,3‐dihydro‐1,5 benzodiazepine derivatives from substituted acetophenones, aryl‐aldehydes and o ‐phenylene diamine using heterogeneous calcium ferrite/graphene oxide (CF/GO) nanocomposite has been reported. The catalyst was prepared by ultrasonication method and characterized by spectral and analytical techniques. The CF/GO nanocomposite was employed for environmentally benign synthesis of 2,3‐dihydro‐1,5 benzodiazepines. The synthesized benzodiazepine derivatives were screened for their antimicrobial activities against various bacteria and fungi. The present synthetic strategy offered several advantages such as excellent yields in short span of time, simple modus operandi, ease of isolation and purification of products, simple recovery and reusability of the catalyst. A tentative mechanism for synthesis of 2,3‐dihydro‐1,5 benzodiazepine using CF/GO nanocatalyst has also been proposed.

中文翻译：

异质铁氧体/氧化石墨烯纳米复合物作为新型可持续催化剂的微波增强生物活性1,5-苯并二氮杂卓合成的更绿色途径

在本文件中，一种新颖的和微波良性协议增强2,3-二氢-苯并二氮杂1,5-衍生物的一锅合成从取代的苯乙酮，芳基醛和ö使用异质铁氧体/氧化石墨烯（CF / GO）纳米复合材料的苯二胺已有报道。该催化剂采用超声方法制备，并通过光谱和分析技术表征。CF / GO纳米复合材料被用于环境友好的2,3-dihydro-1,5苯并二氮杂合成。筛选合成的苯并二氮杂卓衍生物对各种细菌和真菌的抗菌活性。本合成策略提供了许多优点，例如在短时间内的优异产率，简单的操作方式，产物的分离和纯化容易，催化剂的简单回收和可重复使用性。还提出了使用CF / GO纳米催化剂合成2,3-二氢-1,5苯并二氮杂的初步机理。

更新日期：2020-03-16

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