Transfer and loss of allergen‐specific responses via stem cell transplantation: a prospective observational study,Allergy

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Transfer and loss of allergen‐specific responses via stem cell transplantation: a prospective observational study
Allergy ( IF 12.6 ) Pub Date : 2020-06-23 , DOI: 10.1111/all.14278
Markus Debiasi ₁ , Herbert Pichler ₂ , Florian Klinglmüller ₃ , Heidrun Boztug ₂ , Klara Schmidthaler ₁ , Jonas Rech ₁ , David Scherer ₁ , Christian Lupinek ₄ , Rudolf Valenta _{4,

5} , Ewa Kacinska-Pfaller ₂ , Rene Geyeregger ₆ , Gerhard Fritsch ₆ , Oskar A Haas _{2,

6} , Christina Peters ₂ , Thomas Lion _{2,

6} , Mübeccel Akdis _{7,

8} , Susanne Matthes ₂ , Cezmi A Akdis _{7,

8} , Zsolt Szépfalusi ₁ , Thomas Eiwegger _{1,

9,

10,

11}

Affiliation

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
Children's Cancer Research Institute (CCRI), Vienna, Austria.
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
Division of Immunology and Allergy, Food allergy and Anaphylaxis Program, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.
Research Institute, The Hospital for Sick Children, Translational Medicine program, Toronto, Canada.
Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

Currently, no estimates can be made on the impact of hematopoietic stem cell transplantation on allergy transfer or cure of the disease. By using component‐resolved diagnosis, we prospectively investigated 50 donor‐recipient pairs undergoing allogeneic stem cell transplantation. This allowed calculating the rate of transfer or maintenance of allergen‐specific responses in the context of stem cell transplantation.

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