Studies of neutral biomolecules in the gas phase allow for the study of molecular properties in the absence of solvent and charge effects, thus complementing spectroscopic and analytical methods in solution or in ion traps. Some properties, such as the static electronic susceptibility, are best accessed in experiments that act on the motion of the neutral molecules in an electric field. Here, we screen seven peptides for their thermal stability and electron impact ionizability. We identify two tripeptides as sufficiently volatile and thermostable to be evaporated and interfered in the long-baseline universal matter-wave interferometer. Monitoring the deflection of the interferometric molecular nanopattern in a tailored external electric field allows us to measure the static molecular susceptibility of Ala-Trp-Ala and Ala-Ala-Trp bearing fluorinated alkyl chains at C- and N-termini. The respective values are 4 π ε 0 × 330 ± 150 Å 3 and 4 π ε 0 × 270 ± 80 Å 3 .

中文翻译：

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物质波干扰和用氟化烷基链修饰的三肽的偏转。

对气相中性生物分子的研究允许在没有溶剂和电荷影响的情况下研究分子性质，从而补充了溶液或离子阱中的光谱和分析方法。某些特性（例如静态电子敏感性）最好在对电场中的中性分子运动起作用的实验中获得。在这里，我们筛选了七个肽的热稳定性和电子冲击电离性。我们确定了两个三肽具有足够的挥发性和热稳定性，可以蒸发并在长基线通用物质波干涉仪中受到干扰。在定制的外部电场中监测干涉式分子纳米图案的偏转，使我们能够测量在C和N末端带有氟化烷基链的Ala-Trp-Ala和Ala-Ala-Trp的静态分子敏感性。各自的值为4πε0×330±150Å3和4πε0×270±80Å3。