Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes.,ChemBioChem

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Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-17 , DOI: 10.1002/cbic.201900787
Imran T Malik ₁ , Rebeca Pereira _{1,

2} , Marie-Theres Vielberg ₃ , Christian Mayer ₁ , Jan Straetener ₁ , Dhana Thomy ₁ , Kirsten Famulla ₄ , Helena Castro ₂ , Peter Sass ₁ , Michael Groll ₃ , Heike Brötz-Oesterhelt ₁

Affiliation

ClpP mutant analysis : ADEP antibiotics select ClpP out‐of‐function mutations in Firmicutes in vitro . Studying these ClpP defects provides a map of amino acids relevant for the function of ClpP. Several mutated ClpP proteins were purified, and their diverse impairments were characterised. A new S. aureus ClpP:ADEP co‐crystal structure shows an electrostatic network stabilising the N‐terminal gate.

中文翻译：

厚壁菌门中 ClpP 突变赋予对酰基缩肽类抗生素抗性的功能表征。

ClpP 突变分析：ADEP 抗生素在体外选择厚壁菌门中的 ClpP 功能丧失突变。研究这些 ClpP 缺陷提供了与 ClpP 功能相关的氨基酸图谱。纯化了几种突变的 ClpP 蛋白，并表征了它们的不同损伤。一种新的金黄色葡萄球菌ClpP:ADEP 共晶结构显示出稳定 N 端栅极的静电网络。

更新日期：2020-03-17

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