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Expanding the Diversity of Plant Monoterpenoid Indole Alkaloids Employing Human Cytochrome P450 3A4.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-17 , DOI: 10.1002/cbic.202000020
Yuriy V Sheludko 1 , Jascha Volk 1 , Wolfgang Brandt 2 , Heribert Warzecha 1
Affiliation  

Alternative oxidation : We used CYP3A4 for the targeted diversification of plant monoterpenoid indole alkaloids. In vitro and in planta studies proved that the cytochrome mainly converted vinorine into vinorine (19R ,20R )‐epoxide, a new metabolite containing a rare for indole alkaloid epoxide group. A minor route led to the formation of the natural constituent vomilenine.
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中文翻译:

利用人细胞色素P450 3A4扩大植物单萜类吲哚生物碱的多样性。

交替氧化:我们使用CYP3A4进行植物单萜类吲哚生物碱的靶向多样化。在体外和植物中的研究证明,细胞色素主要将长春碱转化为长春碱(19 R,20 R)-环氧化合物,这是一种新的代谢产物,其中吲哚生物碱环氧化合物基团很少见。一条次要路线导致了天然成分伏米林的形成。
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更新日期:2020-03-17
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