β-Diketonate versus β-Ketoiminate: The Importance of a Ferrocenyl Moiety in Improving the Anticancer Potency.,ChemBioChem

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β-Diketonate versus β-Ketoiminate: The Importance of a Ferrocenyl Moiety in Improving the Anticancer Potency.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-16 , DOI: 10.1002/cbic.202000028
Matthew Allison ₁ , Daniel Wilson ₁ , Christopher M Pask ₁ , Patrick C McGowan ₁ , Rianne M Lord _{2,

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Affiliation

The cell seekers : We report the synthesis of new β‐diketonate and β‐ketoiminate ligands that have been functionalized with a ferrocenyl moiety. The ferrocenyl β‐diketonate compounds have high IC₅₀ values and are more selectivity towards cancerous cells, in particular human breast carcinomas. Some compounds are up to 9 times more cytotoxic and selective when compared to carboplatin.

中文翻译：

β-二酮酸盐与 β-酮亚胺酸盐：二茂铁基部分在提高抗癌效力方面的重要性。

细胞探索者：我们报告了新的 β-二酮酸和 β-酮亚胺配体的合成，这些配体已用二茂铁基部分功能化。二茂铁基β-二酮化合物具有高IC ₅₀值，并且对癌细胞（特别是人类乳腺癌）具有更高的选择性。与卡铂相比，某些化合物的细胞毒性和选择性高达 9 倍。

更新日期：2020-03-16

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