Through concentration‐varying selection and bioinformatic analyses, we have identified four classes of DNA aptamers. One of the two new classes is unique in that it can form a 2 : 1 complex with the homodimeric protein VEGF‐165. This work has thus expanded the repertoire of anti‐VEGF‐165 DNA aptamers and created the possibility to engineer a higher‐affinity homodimeric aptamer for VEGF‐165.

中文翻译：

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体外选择人类血管内皮生长因子165的新DNA适体。

通过浓度变化选择和生物信息学分析，我们鉴定出四类DNA适体。这两个新类别之一是独特的，因为它可以与同型二聚体蛋白VEGF-165形成2：1的复合物。因此，这项工作扩大了抗VEGF-165 DNA适体的范围，并为针对VEGF-165设计更高亲和力的同二聚体适体创造了可能性。