With proline at the side : There is increasing interest in using α/β‐peptides as active substances in vivo, hence the investigation of their degradation patterns against enzymes with broad substrate specificity would shed light on potential metabolic routes. An important human enzyme, DPP‐4 cleaves proline‐containing α/β‐peptides with cleavage rates strongly depending on the side‐chain chemistry at the cleavage site.

中文翻译：

---

DPP-4使α/β-肽键断裂：底物特异性和半衰期。

脯氨酸在旁边：在体内使用α/β肽作为活性物质的兴趣日益浓厚，因此，研究其针对具有广泛底物特异性的酶的降解方式将为潜在的代谢途径提供启示。DPP-4是一种重要的人类酶，可裂解脯氨酸中的α/β肽，其裂解速率强烈取决于裂解位点的侧链化学性质。