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Bok-choy promotes growth performance, lipid metabolism and related gene expression in Syrian golden hamsters fed with a high-fat diet
Food & Function ( IF 5.1 ) Pub Date : 2020/03/17 , DOI: 10.1039/c9fo02975c Emal Naseri 1, 2, 3, 4, 5 , Kong Xiangyu 1, 2, 3, 4, 5 , Chunmei Hu 1, 2, 3, 4, 5 , Aliya Ayaz 1, 2, 3, 4, 5 , Mohammad Malyar Rahmani 1, 2, 3, 4, 5 , Maazullah Nasim 1, 2, 3, 4, 5 , Enayatullah Hamdard 1, 2, 3, 4, 5 , Ahmadullah Zahir 1, 2, 3, 4, 5 , Qian Zhou 1, 2, 3, 4, 5 , Jianjun Wang 1, 2, 3, 4, 5 , Xilin Hou 1, 2, 3, 4, 5
Food & Function ( IF 5.1 ) Pub Date : 2020/03/17 , DOI: 10.1039/c9fo02975c Emal Naseri 1, 2, 3, 4, 5 , Kong Xiangyu 1, 2, 3, 4, 5 , Chunmei Hu 1, 2, 3, 4, 5 , Aliya Ayaz 1, 2, 3, 4, 5 , Mohammad Malyar Rahmani 1, 2, 3, 4, 5 , Maazullah Nasim 1, 2, 3, 4, 5 , Enayatullah Hamdard 1, 2, 3, 4, 5 , Ahmadullah Zahir 1, 2, 3, 4, 5 , Qian Zhou 1, 2, 3, 4, 5 , Jianjun Wang 1, 2, 3, 4, 5 , Xilin Hou 1, 2, 3, 4, 5
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Broadly, bok-choy is known for its potential benefits as part of a human diet. However, the effects and deeper investigations of bok-choy on human health are still insufficient. This study aimed to investigate the beneficial effects of two cultivars of bok-choy, ‘Suzhouqing’ (green cultivar) and ‘Ziluolan’ (purple cultivar), on growth performance, lipid metabolism and related gene expressions in Syrian golden hamsters. Fifty six male Syrian golden hamsters (6-months-old) were randomly assigned into 6 groups: normal diet (A), high-fat diet (B), high-fat diet + 5% ‘Suzhouqing’ (C), high-fat diet + 7% ‘Suzhouqing’ (D), high-fat diet + 5% ‘Ziluolan’ (E), and high-fat diet + 7% ‘Ziluolan’ (F), fed for 56 consecutive days. On day 0, 28 and 56, blood and liver samples were collected to examine the lipid profile, liver enzymes, histomorphology and related gene expressions. The results showed that group B had significantly increased levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase, while (P < 0.05) showed impaired levels of high-density lipoprotein cholesterol compared with group A. Group D, E and F had significantly reduced levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase, while the level of high-density lipoprotein cholesterol was significantly increased compared with group B. Remarkably, the mRNA expressions of CEBP-α, DGAT1, lipoprotein lipase (LPL), FASN and 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA) were significantly up-regulated and carnitine palmitoyl transferase 2 (CPT2), Cyp27A1 and proliferator activated receptor alpha (PPAR-α) were significantly down-regulated in group B compared with group A. However, in group D, E and F, the mRNA expression levels of CCAAT enhancer binding protein alpha, DGAT1, LPL, FASN and HMG-CoA were significantly down-regulated and CPT2, Cyp27A1 and PPAR-α were significantly up-regulated compared with group B. In conclusion, different amounts of bok-choy added to the diets incredibly improved the lipid-profile, enhanced liver enzyme activities and related gene expression. The hamsters supplemented with 7% ‘Ziluolan’ exhibited the best performance among all the other high-fat groups, which shows that Ziluolan could be a great alternative for the reduction of fat accumulation and conserving health.
中文翻译：
白菜促进高脂饮食喂养的叙利亚金仓鼠的生长性能，脂质代谢和相关基因表达
广泛来说，白菜因其作为人类饮食的一部分的潜在益处而闻名。但是，白菜对人体健康的影响和深入研究仍不足。这项研究旨在调查两个品种的白菜，“苏州青”（绿色品种）和“紫罗兰”（紫色品种），对叙利亚金仓鼠的生长性能，脂质代谢和相关基因表达的有益影响。将56只雄性叙利亚金仓鼠（6个月大）随机分为6组：正常饮食（A），高脂饮食（B），高脂饮食+ 5％的“苏州青”（C），高脂饮食脂肪饮食+ 7％的“苏州轻”（D），高脂饮食+ 5％的“紫罗兰”（E）和高脂肪饮食+ 7％的“紫罗兰”（F），连续56天。在第0、28和56天，收集血液和肝脏样本以检查血脂，肝酶，组织形态学和相关基因表达。结果显示，B组的总胆固醇，甘油三酸酯，低密度脂蛋白胆固醇，丙氨酸氨基转移酶，天冬氨酸氨基转移酶和碱性磷酸酶水平显着增加，而（P与B组相比，FASN和HMG-CoA显着下调，CPT2，Cyp27A1和PPAR-α显着上调。总之，日粮中添加不同量的白菜极大地改善了血脂，改善了肝脏酶活性和相关基因表达。在所有其他高脂人群中，补充有7％的“兹罗兰”的仓鼠表现出最好的表现，这表明兹罗兰可以成为减少脂肪堆积和保持健康的绝佳选择。
更新日期：2020-03-27
中文翻译：
白菜促进高脂饮食喂养的叙利亚金仓鼠的生长性能，脂质代谢和相关基因表达
广泛来说，白菜因其作为人类饮食的一部分的潜在益处而闻名。但是，白菜对人体健康的影响和深入研究仍不足。这项研究旨在调查两个品种的白菜，“苏州青”（绿色品种）和“紫罗兰”（紫色品种），对叙利亚金仓鼠的生长性能，脂质代谢和相关基因表达的有益影响。将56只雄性叙利亚金仓鼠（6个月大）随机分为6组：正常饮食（A），高脂饮食（B），高脂饮食+ 5％的“苏州青”（C），高脂饮食脂肪饮食+ 7％的“苏州轻”（D），高脂饮食+ 5％的“紫罗兰”（E）和高脂肪饮食+ 7％的“紫罗兰”（F），连续56天。在第0、28和56天，收集血液和肝脏样本以检查血脂，肝酶，组织形态学和相关基因表达。结果显示，B组的总胆固醇，甘油三酸酯，低密度脂蛋白胆固醇，丙氨酸氨基转移酶，天冬氨酸氨基转移酶和碱性磷酸酶水平显着增加，而（P与B组相比，FASN和HMG-CoA显着下调，CPT2，Cyp27A1和PPAR-α显着上调。总之，日粮中添加不同量的白菜极大地改善了血脂，改善了肝脏酶活性和相关基因表达。在所有其他高脂人群中，补充有7％的“兹罗兰”的仓鼠表现出最好的表现，这表明兹罗兰可以成为减少脂肪堆积和保持健康的绝佳选择。
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