A RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of cervical cancer.,Journal of Materials Chemistry B

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A RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of cervical cancer.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-04-02 , DOI: 10.1039/c9tb02937k
Lin Luo ₁ , Furen Zeng , Jiangbo Xie , Jialong Fan , Shengying Xiao , Zhou Wang , Hailong Xie , Bin Liu

Affiliation

Due to the untargeted release of chemical drugs, the efficacy of chemotherapy is often compromised along with serious side effects on patients. Recently, the development of targeted delivery systems using nanomaterials as carriers has provided more alternatives for chemical drug transportation. In this study, we developed a novel targeted nanocomplex of GOQD-ICG-DOX@RBCM-FA NPs (GID@RF NPs). First, PEG modified graphene oxide quantum dots (GOQDs) were used to co-load the photosensitizer of indocyanine green (ICG) and DOX, to form GOQD-ICG-DOX NPs (GID NPs). Then, the red blood cell membrane (RBCM) was applied for GID NP camouflage to avoid immune clearance. Finally, folic acid was used to endow the targeting ability of GID@RF NPs. MTT assay showed that the survival rate of HeLa cells reduced by 71% after treatment with GID@RF NPs and laser irradiation. Meanwhile, membrane camouflage significantly prolonged the blood circulation time and enhanced the immune evading ability of GID NPs. Moreover, the drug accumulation at tumor sites was significantly improved through the strong interaction between FA and FA receptor highly expressed on the tumor cells. In vivo assay demonstrated the strongest tumor growth inhibition ability of the combinational chemo/photothermal therapy. H&E analysis indicated no significant abnormalities in the major organs of mice undergoing GID@RF NPs treatment. The level of blood and biochemical parameters remained stable as compared to the control. In summary, this combinational therapy system provides a safe, rapid and effective alternative for the treatment of cervical cancer in the future.

中文翻译：

RBC膜伪装的仿生纳米平台可增强宫颈癌的化学光热疗法。

由于化学药物的靶向释放，经常会损害化疗的效果以及对患者的严重副作用。近来，使用纳米材料作为载体的靶向递送系统的发展为化学药物运输提供了更多的选择。在这项研究中，我们开发了一种新型靶向纳米复合物GOQD-ICG-DOX @ RBCM-FA NP（GID @ RF NP）。首先，使用PEG修饰的氧化石墨烯量子点（GOQD）共同负载吲哚菁绿（ICG）和DOX的光敏剂，以形成GOQD-ICG-DOX NP（GID NP）。然后，将红细胞膜（RBCM）应用于GID NP伪装以避免免疫清除。最后，叶酸被用来赋予GID @ RF NPs的靶向能力。MTT法检测显示，经GID @ RF NPs和激光照射后，HeLa细胞的存活率降低了71％。同时，膜伪装显着延长了血液循环时间并增强了GID NP的免疫逃避能力。此外，通过FA和在肿瘤细胞上高度表达的FA受体之间的强相互作用，显着改善了在肿瘤部位的药物蓄积。体内试验证明了化学/光热疗法联合治疗对肿瘤的最强抑制能力。H＆E分析表明，接受GID @ RF NPs处理的小鼠的主要器官没有明显异常。与对照相比，血液和生化参数水平保持稳定。总而言之，这种组合治疗系统可提供安全，

更新日期：2020-03-17

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