Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-03-17 , DOI: 10.1039/d0qo00161a
Zhan-Yong Wang _{1,

2,

3,

4} , Ting Yang _{2,

3,

4,

5} , Kai-Kai Wang _{1,

2,

3,

4} , Rongxiang Chen _{1,

2,

3,

4} , Menghan Liu _{1,

2,

3,

4} , Hongxin Liu _{6,

7,

8,

9,

10}

Affiliation

A facile route to benzofuran-fused δ-lactones was developed via an N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction, giving the expected products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). It should be noted that benzofuran-fused pyrones can be obtained stepwise in one pot with excellent yields (up to 96%) by using this methodology.

中文翻译：

烯类与苯并呋喃-3-酮的氧化性N-杂环卡宾催化的[3 + 3]环化反应：有效获得苯并呋喃稠合的δ-内酯

通过N杂环卡宾催化的[3 + 3]环化反应，开发了一种易于获得苯并呋喃稠合的δ-内酯的途径，从而以高收率（高达99％）和优异的对映选择性（高达98％ee）提供了预期的产物）。应当指出，通过使用这种方法，可以在一个锅中逐步获得苯并呋喃稠合的吡喃酮，收率极好（高达96％）。

更新日期：2020-04-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11