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Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-03-17 , DOI: 10.1039/d0qo00161a
Zhan-Yong Wang 1, 2, 3, 4 , Ting Yang 2, 3, 4, 5 , Kai-Kai Wang 1, 2, 3, 4 , Rongxiang Chen 1, 2, 3, 4 , Menghan Liu 1, 2, 3, 4 , Hongxin Liu 6, 7, 8, 9, 10
Affiliation  

A facile route to benzofuran-fused δ-lactones was developed via an N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction, giving the expected products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). It should be noted that benzofuran-fused pyrones can be obtained stepwise in one pot with excellent yields (up to 96%) by using this methodology.

中文翻译:

烯类与苯并呋喃-3-酮的氧化性N-杂环卡宾催化的[3 + 3]环化反应:有效获得苯并呋喃稠合的δ-内酯

通过N杂环卡宾催化的[3 + 3]环化反应,开发了一种易于获得苯并呋喃稠合的δ-内酯的途径,从而以高收率(高达99%)和优异的对映选择性(高达98%ee)提供了预期的产物)。应当指出,通过使用这种方法,可以在一个锅中逐步获得苯并呋喃稠合的吡喃酮,收率极好(高达96%)。
更新日期:2020-04-24
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