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Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
Green Chemistry ( IF 9.3 ) Pub Date : 2020-03-18 , DOI: 10.1039/d0gc00137f
José S. S. Neto 1, 2, 3, 4 , Renata A. Balaguez 2, 3, 4, 5 , Marcelo S. Franco 1, 2, 3, 4 , Victor C. de Sá Machado 1, 2, 3, 4 , Sumbal Saba 4, 6, 7, 8 , Jamal Rafique 4, 9, 10, 11 , Fábio Z. Galetto 2, 3, 4, 5 , Antonio L. Braga 1, 2, 3, 4
Affiliation  

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.

中文翻译:

乙醇中的三卤异氰尿酸:咪唑-杂芳烃区域选择性卤化的生态友好系统

在这里,我们描述了使用乙醇中的三卤代异氰尿酸对2-芳基咪唑[1,2- a ]吡啶进行直接C(sp 2)-H键卤化(Cl,Br,I)的有效,快速和良性方案。此外,这种可持续的协议已成功扩展到咪唑并嘧啶,咪唑并噻唑和吲唑杂环,显示了这种有用方法的广泛性。
更新日期:2020-03-18
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