Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes,Green Chemistry

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Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
Green Chemistry ( IF 9.3 ) Pub Date : 2020-03-18 , DOI: 10.1039/d0gc00137f
José S. S. Neto _{1,

2,

3,

4} , Renata A. Balaguez _{2,

3,

4,

5} , Marcelo S. Franco _{1,

2,

3,

4} , Victor C. de Sá Machado _{1,

2,

3,

4} , Sumbal Saba _{4,

6,

7,

8} , Jamal Rafique _{4,

9,

10,

11} , Fábio Z. Galetto _{2,

3,

4,

5} , Antonio L. Braga _{1,

2,

3,

4}

Affiliation

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp²)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.

中文翻译：

乙醇中的三卤异氰尿酸：咪唑-杂芳烃区域选择性卤化的生态友好系统

在这里，我们描述了使用乙醇中的三卤代异氰尿酸对2-芳基咪唑[1,2- a ]吡啶进行直接C（sp ²）-H键卤化（Cl，Br，I）的有效，快速和良性方案。此外，这种可持续的协议已成功扩展到咪唑并嘧啶，咪唑并噻唑和吲唑杂环，显示了这种有用方法的广泛性。

更新日期：2020-03-18

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