Anthropogenic landscapes increase Campylobacter jejuni infections in urbanizing banded mongoose (Mungos mungo): A one health approach.,PLOS Neglected Tropical Diseases

当前位置： X-MOL 学术 › PLOS Negl. Trop. Dis. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Anthropogenic landscapes increase Campylobacter jejuni infections in urbanizing banded mongoose (Mungos mungo): A one health approach.
PLOS Neglected Tropical Diseases ( IF 3.4 ) Pub Date : 2020-03-17 , DOI: 10.1371/journal.pntd.0007888
Sarah Medley _{1,

2} , Monica Ponder ₃ , Kathleen A Alexander _{1,

2}

Affiliation

BACKGROUND Campylobacter is a common, but neglected foodborne-zoonotic pathogen, identified as a growing cause of foodborne disease worldwide. Wildlife and domestic animals are considered important reservoirs, but little is known about pathogen infection dynamics in free-ranging mammalian wildlife particularly in sub-Saharan Africa. In countries like Botswana, there is significant overlap between humans and wildlife, with the human population having one of the highest HIV infection rates in the world, increasing vulnerability to infection. METHODOLOGY/PRINCIPAL FINDINGS We investigated Campylobacter occurrence in archived human fecal samples (children and adults, n = 122, 2011), feces from free-ranging banded mongooses (Mungos mungo, n = 201), surface water (n = 70), and river sediment samples (n = 81) collected in 2017 from the Chobe District, northern Botswana. Campylobacter spp. was widespread in humans (23.0%, 95% CI 13.9-35.4%), with infections dominantly associated with C. jejuni (82.1%, n = 28, 95% CI 55.1-94.5%). A small number of patients presented with asymptomatic infections (n = 6). While Campylobacter spp. was rare or absent in environmental samples, over half of sampled mongooses tested positive (56%, 95% CI 45.6-65.4%). Across the urban-wilderness continuum, we found significant differences in Campylobacter spp. detection associated with the type of den used by study mongooses. Mongooses utilizing man-made structures as den sites had significantly higher levels of C. jejuni infection (p = 0.019) than mongooses using natural dens. Conversely, mongooses using natural dens had overall higher levels of detection of Campylobacter at the genus level (p = 0.001). CONCLUSIONS These results suggest that landscape features may have important influences on Campylobacter species exposure and transmission dynamics in wildlife. In particular, data suggest that human-modified landscapes may increase C. jejuni infection, a primarily human pathogen, in banded mongooses. Pathogen circulation and transmission in urbanizing wildlife reservoirs may increase human vulnerability to infection, findings that may have critical implications for both public and animal health in regions where people live in close proximity to wildlife.

中文翻译：

在城市化的带状猫鼬（Mungos mungo）中，人为景观增加了空肠弯曲杆菌感染：一种健康方法。

背景技术弯曲杆菌是一种常见的但被忽略的食源性动物病原体，已被确定为全球食源性疾病的增长原因。野生动物和家畜被认为是重要的水库，但是对于自由放养的哺乳动物野生生物，尤其是在撒哈拉以南非洲，病原体的感染动态知之甚少。在像博茨瓦纳这样的国家中，人类与野生动植物之间存在大量重叠，人口是世界上艾滋病毒感染率最高的国家之一，这使得人们更容易受到感染。方法/主要发现我们调查了存档人类粪便样本（儿童和成人，n = 122，2011），自由放养带状猫鼬（Mungos mungo，n = 201），地表水（n = 70）和粪便中弯曲杆菌的发生情况。 2017年从乔贝区收集的河流沉积物样本（n = 81）博茨瓦纳北部。弯曲杆菌属。在人中普遍存在（23.0％，95％CI 13.9-35.4％），感染主要与空肠弯曲杆菌有关（82.1％，n = 28，95％CI 55.1-94.5％）。少数患者出现无症状感染（n = 6）。而弯曲杆菌属。在环境样品中非常罕见或缺失，一半以上的猫鼬测试为阳性（56％，95％CI 45.6-65.4％）。在整个城市与荒野的连续体中，我们发现弯曲杆菌属物种之间存在显着差异。与研究猫鼬使用的窝类型相关的检测。使用人造结构作为巢穴的猫鼬与使用天然巢穴的猫鼬相比，空肠弯曲杆菌感染的水平显着更高（p = 0.019）。相反，使用天然巢穴的猫鼬在属水平上检测弯曲杆菌的总体水平较高（p = 0.001）。结论这些结果表明，景观特征可能对弯曲杆菌物种的暴露和野生动植物的传播动态产生重要影响。特别是，数据表明，人为改变的景观可能会增加带状猫鼬中空肠弯曲杆菌的感染，而空肠弯曲杆菌是一种主要的人类病原体。城市化野生动植物库中的病原体循环和传播可能增加人类对感染的脆弱性，这一发现可能对人们居住在野生动植物附近的地区的公共和动物健康产生重大影响。

更新日期：2020-03-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11