当前位置：
X-MOL 学术
›
PLOS Negl. Trop. Dis.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Immunogenicity of a killed bivalent whole cell oral cholera vaccine in forcibly displaced Myanmar nationals in Cox's Bazar, Bangladesh.
PLOS Neglected Tropical Diseases ( IF 3.4 ) Pub Date : 2020-03-16 , DOI: 10.1371/journal.pntd.0007989 Fahima Chowdhury 1 , Taufiqur Rahman Bhuiyan 1 , Afroza Akter 1 , Md Saruar Bhuiyan 1 , Ashraful Islam Khan 1 , Motaher Hossain 1 , Imam Tauheed 1 , Tasnuva Ahmed 1 , Shaumik Islam 1 , Tanzeem Ahmed Rafique 1 , Shah Alam Siddique 1 , Nabila Binta Harun 1 , Khaleda Islam 2 , John D Clemens 1, 3, 4 , Firdausi Qadri 1
PLOS Neglected Tropical Diseases ( IF 3.4 ) Pub Date : 2020-03-16 , DOI: 10.1371/journal.pntd.0007989 Fahima Chowdhury 1 , Taufiqur Rahman Bhuiyan 1 , Afroza Akter 1 , Md Saruar Bhuiyan 1 , Ashraful Islam Khan 1 , Motaher Hossain 1 , Imam Tauheed 1 , Tasnuva Ahmed 1 , Shaumik Islam 1 , Tanzeem Ahmed Rafique 1 , Shah Alam Siddique 1 , Nabila Binta Harun 1 , Khaleda Islam 2 , John D Clemens 1, 3, 4 , Firdausi Qadri 1
Affiliation
|
After the large influx of Rohingya nationals (termed Forcibly Displaced Myanmar National; FDMN) from Rakhine State of Myanmar to Cox's Bazar in Bangladesh, it was apparent that outbreaks of cholera was very likely in this setting where people were living under adverse water and sanitation conditions. Large campaigns of oral cholera vaccine (OCV) were carried out as a preemptive measure to control cholera epidemics. The aim of the study was to evaluate the immune responses of healthy adults and children after administration of two doses of OCV at 14 days interval in FDMN population and compare with the response observed in Bangladeshi's vaccinated earlier. A cross-sectional immunogenicity study was conducted among FDMNs of three age cohort; in adults (18+years; n = 83), in older children (6-17 years; n = 63) and in younger children (1-5 years; n = 80). Capillary blood was collected at three time points to measure vibriocidal antibodies using either plasma or dried blood spot (DBS) specimens. There was a significant increase of responder frequency of vibriocidal antibody titer at day 14 in all groups for Vibrio cholerae O1 (Ogawa/Inaba: adults-64%/64%, older children-70%/89% and younger children-51%/75%). There was no overall difference of vibriocidal antibody titer between FDMN and Bangladeshi population at baseline (p = 0.07-0.08) and at day 14, day 28 in all age groups for both serotypes. The seroconversion rate and geometric mean titer (GMT) of either serotype were comparable using both plasma and DBS specimens. These results showed that OCV is capable of inducing robust immune responses in adults and children among the FDMN population which is comparable to that seen in Bangladeshi participants in different age groups or that reported from other cholera endemic countries. Our results also suggest that the displaced population were exposed to V. cholerae prior to seeking shelter in Bangladesh.
中文翻译：
孟加拉国考克斯巴扎尔的一名被迫流离失所的缅甸国民被杀死的二价全细胞口服霍乱疫苗的免疫原性。
在罗兴亚人（缅甸人被迫流离失所的国民； FDMN）从缅甸若开邦大量涌入孟加拉国的考克斯巴扎尔之后，很明显，在这种情况下，人们生活在不利的水和卫生条件下，很可能爆发了霍乱。 。开展了大规模的口服霍乱疫苗（OCV）运动，作为控制霍乱流行的先发措施。该研究的目的是评估在FDMN人群中，每隔14天服用两剂OCV后，健康成年人和儿童的免疫反应，并将其与孟加拉国早期接种的疫苗进行比较。在三个年龄组的FDMN之间进行了横断面免疫原性研究。成人（18岁以上； n = 83），大龄儿童（6-17岁）；n = 63）和年龄较小的儿童（1-5岁； n = 80）。在三个时间点收集毛细血管血，以使用血浆或干血斑（DBS）标本测量杀线虫抗体。在第14天，霍乱弧菌O1的所有组中，杀弧菌抗体滴度的响应者频率显着增加（小川/稻叶：成人-64％/ 64％，年龄较大的儿童-70％/ 89％，年龄较小的儿童-51％/ 75％）。在两种血清型的所有年龄组中，FDMN和孟加拉国人群的基线（p = 0.07-0.08）和第14天，第28天时，杀螨抗体的滴度没有总体差异。使用血浆和DBS标本，两种血清型的血清转化率和几何平均滴度（GMT）均相当。这些结果表明，OCV能够在FDMN人群中的成年人和儿童中诱导强大的免疫反应，这与不同年龄组的孟加拉国参与者或其他霍乱流行国家的报道相近。我们的结果还表明，在孟加拉国寻求庇护之前，流离失所者已暴露于霍乱弧菌。
更新日期：2020-03-19
中文翻译：
孟加拉国考克斯巴扎尔的一名被迫流离失所的缅甸国民被杀死的二价全细胞口服霍乱疫苗的免疫原性。
在罗兴亚人（缅甸人被迫流离失所的国民； FDMN）从缅甸若开邦大量涌入孟加拉国的考克斯巴扎尔之后，很明显，在这种情况下，人们生活在不利的水和卫生条件下，很可能爆发了霍乱。 。开展了大规模的口服霍乱疫苗（OCV）运动，作为控制霍乱流行的先发措施。该研究的目的是评估在FDMN人群中，每隔14天服用两剂OCV后，健康成年人和儿童的免疫反应，并将其与孟加拉国早期接种的疫苗进行比较。在三个年龄组的FDMN之间进行了横断面免疫原性研究。成人（18岁以上； n = 83），大龄儿童（6-17岁）；n = 63）和年龄较小的儿童（1-5岁； n = 80）。在三个时间点收集毛细血管血，以使用血浆或干血斑（DBS）标本测量杀线虫抗体。在第14天，霍乱弧菌O1的所有组中，杀弧菌抗体滴度的响应者频率显着增加（小川/稻叶：成人-64％/ 64％，年龄较大的儿童-70％/ 89％，年龄较小的儿童-51％/ 75％）。在两种血清型的所有年龄组中，FDMN和孟加拉国人群的基线（p = 0.07-0.08）和第14天，第28天时，杀螨抗体的滴度没有总体差异。使用血浆和DBS标本，两种血清型的血清转化率和几何平均滴度（GMT）均相当。这些结果表明，OCV能够在FDMN人群中的成年人和儿童中诱导强大的免疫反应，这与不同年龄组的孟加拉国参与者或其他霍乱流行国家的报道相近。我们的结果还表明，在孟加拉国寻求庇护之前，流离失所者已暴露于霍乱弧菌。
京公网安备 11010802027423号