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Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis
Journal of Crohn's and Colitis ( IF 8.3 ) Pub Date : 2020-03-16 , DOI: 10.1093/ecco-jcc/jjaa054 Stephanie M Slevin 1 , Lucy C Garner 1 , Conor Lahiff 1 , Malcolm Tan 1 , Lai Mun Wang 2 , Helen Ferry 1 , Borgel Greenaway 1 , Kate Lynch 1 , Alessandra Geremia 1 , Stephen Hughes 3 , Karen Leavens 3 , David Krull 4 , Daniel J B Marks 3 , Katherine Nevin 3 , Kevin Page 3 , Naren Srinivasan 3 , Ruth Tarzi 3 , Paul Klenerman 1, 5 , Simon Travis 1 , Carolina V Arancibia-Cárcamo 1 , Satish Keshav 1
Journal of Crohn's and Colitis ( IF 8.3 ) Pub Date : 2020-03-16 , DOI: 10.1093/ecco-jcc/jjaa054 Stephanie M Slevin 1 , Lucy C Garner 1 , Conor Lahiff 1 , Malcolm Tan 1 , Lai Mun Wang 2 , Helen Ferry 1 , Borgel Greenaway 1 , Kate Lynch 1 , Alessandra Geremia 1 , Stephen Hughes 3 , Karen Leavens 3 , David Krull 4 , Daniel J B Marks 3 , Katherine Nevin 3 , Kevin Page 3 , Naren Srinivasan 3 , Ruth Tarzi 3 , Paul Klenerman 1, 5 , Simon Travis 1 , Carolina V Arancibia-Cárcamo 1 , Satish Keshav 1
Affiliation
Lymphocyte activation gene [LAG]-3 is an immune checkpoint and its expression identifies recently activated lymphocytes that may contribute to inflammation. We investigated the role of LAG-3 by analysing its expression and function in immune cells from blood and tissue of patients with ulcerative colitis [UC].
中文翻译：
淋巴细胞激活基因 (LAG)-3 与溃疡性结肠炎的黏膜炎症和疾病活动有关
淋巴细胞激活基因 [LAG]-3 是一个免疫检查点，其表达可识别最近激活的可能导致炎症的淋巴细胞。我们通过分析其在溃疡性结肠炎 [UC] 患者血液和组织的免疫细胞中的表达和功能来研究 LAG-3 的作用。
更新日期：2020-03-16
中文翻译：
淋巴细胞激活基因 (LAG)-3 与溃疡性结肠炎的黏膜炎症和疾病活动有关
淋巴细胞激活基因 [LAG]-3 是一个免疫检查点，其表达可识别最近激活的可能导致炎症的淋巴细胞。我们通过分析其在溃疡性结肠炎 [UC] 患者血液和组织的免疫细胞中的表达和功能来研究 LAG-3 的作用。
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