T-cell receptors (TCRs) are immune proteins that primarily target peptide antigens presented by the major histocompatibility complex. They tend to have lower specificity and affinity than their antibody counterparts, and their binding sites have been shown to adopt multiple conformations, which is potentially an important factor for their polyspecificity. None of the current TCR-modelling tools predict this variability which limits our ability to accurately predict TCR binding.

中文翻译：

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TCRBuilder：多状态T细胞受体结构预测。

T细胞受体（TCR）是主要针对主要组织相容性复合物呈递的肽抗原的免疫蛋白。它们倾向于比其抗体对应物具有更低的特异性和亲和力，并且它们的结合位点已被证明采用多种构象，这可能是其多特异性的重要因素。当前的TCR建模工具都无法预测这种可变性，从而限制了我们准确预测TCR结合的能力。