In their Correspondence in The Lancet Diabetes & Endocrinology, Roy Gerona and colleagues highlighted a substantial underestimation of levels of bisphenol A (BPA) and its metabolites in urine samples when using a widely accepted method of measurement based on indirect evaluation. Concerns about BPA and the potential effects of its widespread use in commercial everyday products, including plastic bottles and food-can linings, on human health have existed for decades. Leaching of BPA into food and drink that are subsequently ingested is thought to be the biggest route of exposure in humans. In rodent models, in-utero exposure to BPA results in epigenetic changes, causing increased binding of oestrogen receptors to hormone response elements. Although, the effects of BPA on human health have still not been fully assessed, epigenetic changes in utero could have far reaching consequences. Perceptions that BPA is present in low levels has led regulators to be dismissive about its potential adverse health effects, even though the potential for continuous, low-level exposure is present throughout our lifetime.

中文翻译：

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BPA和风险评估。

在《柳叶刀》糖尿病与内分泌学的通讯中Roy Gerona及其同事强调，当使用基于间接评估的广泛接受的测量方法时，尿液样品中的双酚A（BPA）及其代谢物的水平被大大低估了。关于双酚A及其广泛用于商业日用产品（包括塑料瓶和食品罐头衬里）对人体健康的潜在影响已存在数十年。人们认为，将双酚A浸入食物和饮料中是随后摄入的最大途径。在啮齿动物模型中，子宫内暴露于BPA会导致表观遗传变化，从而导致雌激素受体与激素反应元件的结合增加。尽管尚未完全评估BPA对人体健康的影响，但子宫内的表观遗传变化可能会产生深远的影响。