In this research work, graphene/cobalt nanocomposites are functionalized with polyethylene glycol (PEG) to be a platform for theranostics application and antibacterial activity. The non-covalent functionalization of PEG on the surfaces of nanocomposites improved their stability and diminished their cytotoxicity. The PEGylated nanocomposites are demonstrated to allow simultaneous administration of two cancer therapy methods such as magnetic fluids hyperthermia (MFH) which is carried out by converting magnetic energy into heat through ferromagnetic cobalt nanoparticles and heat generation through near-infrared optical absorption by the reduced graphene oxide. A concise simulation is carried out to approximate in vivo conditions and provide a glimpse of practical PEGylated nanocomposites performance. Furthermore, we demonstrate the antimicrobial activity of the PEGylated nanocomposites against Gram-negative Escherichia coli bacteria under alternative current magnetic field (AMF). The graphene/cobalt/PEG (rGO/Co/PEG) nanocomposites show antibacterial activity toward E. coli bacteria of about 100%, when the bacteria intact with nanocomposites are placed under AMF for 15 min. For comparison, the antimicrobial activities of graphene/PEG sheets and cobalt/PEG nanoparticles are also checked. This study concentrates on the design of novel non-toxic PEGylated nanocomposites to be used for dual hyperthermia therapy and bacteria killing by MFH treatments.

中文翻译：

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用于加热应用的聚乙二醇化磁性石墨烯纳米复合材料的热疗响应和使用磁流体热疗加速抗菌活性

在这项研究工作中，石墨烯/钴纳米复合材料用聚乙二醇 (PEG) 进行功能化，成为治疗诊断学应用和抗菌活性的平台。纳米复合材料表面 PEG 的非共价功能化提高了它们的稳定性并降低了它们的细胞毒性。聚乙二醇化纳米复合材料被证明允许同时施用两种癌症治疗方法，例如磁流体热疗 (MFH)，通过铁磁性钴纳米颗粒将磁能转化为热量，并通过还原氧化石墨烯的近红外光吸收产生热量。 . 进行简明的模拟以近似体内条件并提供实用的聚乙二醇化纳米复合材料性能的一瞥。此外，我们证明了聚乙二醇化纳米复合材料在交流磁场（AMF）下对革兰氏阴性大肠杆菌的抗菌活性。石墨烯/钴/PEG (rGO/Co/PEG) 纳米复合材料对大肠杆菌的抗菌活性约为 100%，当将纳米复合材料完整的细菌置于 AMF 下 15 分钟时。为了进行比较，还检查了石墨烯/PEG 片和钴/PEG 纳米颗粒的抗菌活性。本研究集中于设计新型无毒聚乙二醇化纳米复合材料，用于双热疗和 MFH 治疗的细菌杀灭。石墨烯/钴/PEG (rGO/Co/PEG) 纳米复合材料对大肠杆菌的抗菌活性约为 100%，当将纳米复合材料完整的细菌置于 AMF 下 15 分钟时。为了进行比较，还检查了石墨烯/PEG 片和钴/PEG 纳米颗粒的抗菌活性。本研究集中于设计新型无毒聚乙二醇化纳米复合材料，用于双热疗和 MFH 治疗的细菌杀灭。石墨烯/钴/PEG (rGO/Co/PEG) 纳米复合材料对大肠杆菌的抗菌活性约为 100%，当将纳米复合材料完整的细菌置于 AMF 下 15 分钟时。为了进行比较，还检查了石墨烯/PEG 片和钴/PEG 纳米颗粒的抗菌活性。本研究集中于设计新型无毒聚乙二醇化纳米复合材料，用于双热疗和 MFH 治疗的细菌杀灭。