Purpose

The β2-adrenergic receptor (β2AR) is highly expressed in various human cancers. The prognostic significance of its expression in patients with colorectal cancer (CRC) remains unclear. The aim of this study was to assess the prognostic role of β2AR expression in patients with surgically resected CRC.

Methods

One hundred and forty-seven patients with surgically resected CRC were examined using immunohistochemistry. The expression of β2AR was assessed in the specimens of resected primary tumors.

Results

β2AR was expressed in 52.3% of the patients’ tumors. β2AR expression was significantly associated with T factor, N factor, and tumor cell proliferation (Ki-67 labeling index). Univariate analysis demonstrated that T factor, N factor, tumor stage, lymphatic permeation, vascular invasion, perineural invasion, β2AR expression, and Ki-67 labeling index were significant prognostic factors for worse disease-free survival (DFS); all but T factor were also significant predictors for worse overall survival (OS). Multivariate analysis confirmed that expression of β2AR was a significant prognostic marker for predicting worse DFS and OS.

Conclusion

β2AR expression was identified as a significant independent prognostic factor in patients with surgically resected CRC.

中文翻译：

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β2-肾上腺素能受体表达在手术切除的结直肠癌患者中的预后意义。

目的

β2-肾上腺素能受体 (β2AR) 在各种人类癌症中高度表达。其表达在结直肠癌 (CRC) 患者中的预后意义仍不清楚。本研究的目的是评估 β2AR 表达在手术切除的 CRC 患者中的预后作用。

方法

使用免疫组织化学检查了 147 名手术切除的 CRC 患者。在切除的原发肿瘤标本中评估β2AR的表达。

结果

β2AR 在 52.3% 的患者肿瘤中表达。β2AR 表达与 T 因子、N 因子和肿瘤细胞增殖（Ki-67 标记指数）显着相关。单因素分析表明，T因子、N因子、肿瘤分期、淋巴管浸润、血管浸润、神经周围浸润、β2AR表达和Ki-67标记指数是无病生存期（DFS）较差的重要预后因素；除 T 因子外，其他所有因子也是总体生存率 (OS) 较差的重要预测因子。多变量分析证实，β2AR 的表达是预测 DFS 和 OS 恶化的重要预后标志物。

结论

β2AR 表达被确定为手术切除的 CRC 患者的重要独立预后因素。