Objectives

This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B.

Methods

Sixty patients with Child–Pugh grade A (CP-A), 18 with Child–Pugh grade B (CP-B), 2 with Child–Pugh grade C (CP-C), and 20 with normal liver function (NLF) were enrolled. Gadolinium ethoxybenzyldiethy-lenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was conducted. T1 mapping imaging was performed before and 20 min after Gd-EOB-DTPA administration. The pre- and post-contrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (ΔR1), rate of decrease in the T1 relaxation time (ΔT1), HEF, and uptake coefficient (K) parameters in the NLF, CP-A, and CP-B + CP-C groups were compared using one-way analysis of variance. The effectiveness of each parameter in differentiating the NLF + CP-A group from the CP-B + CP-C group was evaluated using the receiver operating characteristic (ROC) curve.

Results

The HEF, K, ΔT1, and ΔR1 values decreased, while the T1post and T1pre values increased, with the increase in liver function damage. Significant differences in T1post, ΔT1, ΔR1, and HEF were found between different groups, except for the CP-A and NLF groups. However, no significant difference was observed in the T1pre among the three groups. HEF exhibited the largest area under the ROC curve.

Conclusion

The HEF is an effective method for evaluating liver function in patients with hepatitis B.

中文翻译：

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基于钆塞酸增强 MRI 的肝细胞增强分数评估慢性乙型肝炎患者的肝功能。

目标

本研究旨在评估使用基于钆塞酸增强磁共振成像 (MRI) 的肝细胞增强分数 (HEF) 评估慢性乙型肝炎患者肝功能的可行性。

方法

Child-Pugh A级（CP-A）60例，Child-Pugh B级（CP-B）18例，Child-Pugh C级（CP-C）2例，肝功能正常（NLF）20例注册。进行了钆乙氧基苄基二乙基-来三胺五乙酸 (Gd-EOB-DTPA) 增强的 MRI。T1 映射成像在 Gd-EOB-DTPA 给药之前和之后 20 分钟进行。肝脏造影前后 T1 值（T1pre 和 T1post）、T1 弛豫率增加（ΔR1）、T1 弛豫时间减少率（ΔT1）、HEF 和​​摄取系数（K) 使用单向方差分析比较 NLF、CP-A 和 CP-B + CP-C 组中的参数。使用受试者工作特征 (ROC) 曲线评估每个参数在区分 NLF + CP-A 组与 CP-B + CP-C 组方面的有效性。

结果

HEF、K、ΔT1和ΔR1值随着肝功能损害的增加而降低，而T1post和T1pre值升高。除 CP-A 和 NLF 组外，不同组之间的 T1post、ΔT1、ΔR1 和 HEF 存在显着差异。然而，三组之间的 T1pre 没有观察到显着差异。HEF 表现出最大的 ROC 曲线下面积。

结论

HEF是评估乙型肝炎患者肝功能的有效方法。