Abstract Owing to their versatile chemistry, polyaspartamides have recently attracted increased interest in various biomedical uses such as drug delivery systems and scaffolding materials. Solubility of these polymers in organic solvents and in water at certain values of pH can be fine-tuned by their chemical composition, which was exploited here to fabricate fast-dissolving electrospun matrices in ethanol with no additives. Various side groups were tested to control the solubility of the polymers as well as the morphology and moisture uptake of the matrices produced. Tertiary amine groups were immobilized to ensure high solubility around neutral pH, while modification with alkyl side groups limited moisture uptake. Finally, 3-(diethylamino)propyl and n-butyl side groups were used in equal amounts. The effect of viscosity, surface tension and specific conductivity of polymer solutions on the fiber morphology was determined in order to optimize the conditions for preparing fibers with a narrow size distribution and large specific surface area. The polymer withstood the electrospinning process without any chemical degradation, as determined by IR, and was thermally stable. Furthermore, the matrices exhibited a glass transition temperature above room temperature. The complete release of vitamin B12 was observed within one minute due to the fast dissolution of the matrices in simulated salivary fluid at pH = 6.8, supporting the potential of the developed materials in oral drug delivery.

中文翻译：

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聚天冬酰胺静电纺丝制备的快速溶解纳米纤维基质

摘要 由于其多用途的化学性质，聚天冬酰胺最近在各种生物医学用途（例如药物递送系统和支架材料）中引起了越来越多的兴趣。这些聚合物在有机溶剂和特定 pH 值下的水中的溶解度可以通过它们的化学成分进行微调，这里利用化学成分在乙醇中制造快速溶解的电纺基质，没有​​添加剂。测试了各种侧基以控制聚合物的溶解度以及所产生基质的形态和水分吸收。叔胺基团被固定以确保在中性 pH 值附近具有高溶解度，而烷基侧基的修饰限制了水分的吸收。最后，以等量使用3-(二乙氨基)丙基和正丁基侧基。粘度的影响，确定聚合物溶液的表面张力和比电导率对纤维形态的影响，以优化制备具有窄尺寸分布和大比表面积的纤维的条件。该聚合物经受住了静电纺丝过程而没有任何化学降解，如红外检测那样，并且是热稳定的。此外，基质表现出高于室温的玻璃化转变温度。由于基质在 pH = 6.8 的模拟唾液液中快速溶解，因此在一分钟内观察到维生素 B12 的完全释放，支持所开发材料在口服给药方面的潜力。