Araticum (Annona crassiflora Mart.) is a native fruit from Brazilian Cerrado widely used by folk medicine. Nevertheless, the biological effects of its seeds and peel have not been extensively evaluated. We evaluate herein the antioxidant, antiproliferative and healing potential of araticum peel and seeds extracts. HPLC-ESI-MS/MS analysis showed flavonoids, namely epicatechin and quercetin, as the main compounds in peel and seeds extracts, respectively. These extracts showed high content of phenolic compounds (7254.46 and 97.74 µg/g extract) and, as consequence, high antioxidant capacity. Interesting, the seeds extract was more effective than peel extract against all tested cancer cells, especially on NCI-ADR/RES (multidrug resistant ovary adenocarcinoma) cell line. In the cell migration assay by using HaCaT (keratinocyte), the seeds extract induced migration, while the peel extract showed an inhibitory effect. In this way, phenolic content could be related to antioxidant capacity, but it was not related to antiproliferative and healing effect. The araticum seeds extract showed an interesting response to in vitro biological assay although of its low content of phenolic compounds. Unidentified compounds, such as alkaloids and annonaceous acetogenins could be related to it. Araticum has potential to be used as therapeutic plant especially as antiproliferative and healing drug.

菊苣（Annona crassifloraMart。）是巴西Cerrado的本地水果，被民间医学广泛使用。然而，尚未对其种子和果皮的生物学效应进行广泛评估。我们在这里评估了花生果皮和种子提取物的抗氧化，抗增殖和愈合潜力。HPLC-ESI-MS / MS分析表明，类黄酮（表儿茶素和槲皮素）分别是果皮和种子提取物中的主要化合物。这些提取物显示出高含量的酚类化合物（7254.46和97.74 µg / g提取物），因此具有很高的抗氧化能力。有趣的是，种子提取物比果皮提取物对所有测试的癌细胞更有效，尤其是在NCI-ADR / RES（多药耐药卵巢腺癌）细胞系上。在使用HaCaT（角质形成细胞）进行的细胞迁移分析中，种子提取物诱导了迁移，而果皮提取物表现出抑制作用。这样，酚含量可能与抗氧化能力有关，但与抗增殖和愈合作用无关。花生种子提取物对体外生物测定法，尽管其酚类化合物含量低。身份不明的化合物，如生物碱和无水产乙酸甘油酯可能与此有关。菊苣有潜力用作治疗植物，尤其是用作抗增殖和康复药物。