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Dietary exposure assessment of sum deoxynivalenol forms, sum T-2/HT-2 toxins and zearalenone from cereal-based foods and beer.
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2020-03-18 , DOI: 10.1016/j.fct.2020.111280
Vladimir Ostry 1 , Marcela Dofkova 2 , Jitka Blahova 2 , Frantisek Malir 3 , Radek Kavrik 2 , Irena Rehurkova 2 , Jiri Ruprich 2
Affiliation  

A dietary exposure assessment to sum of deoxynivalenol (DON) forms, sum of T-2/HT-2 toxins (T2/HT2) and zearalenone (ZEA) was conducted for Czech children 4-6 years and Czech men and women 18-59 years. Retail foods (25 different commodities, n = 336) were assessed by LC-MS/MS methods. The 95th percentile chronic exposure to sum of DON forms was determined in children from 648 to 1030 ng/kg bw/day (LB/lower bound/and UB/upper bound/), in men from 362 to 923 ng/kg bw/day and in women from 272 to 490 ng/kg bw/day. The 95th percentile chronic exposure to sum T2/HT2 was determined in children from 6.5 to 31 ng/kg bw/day, in men from 1.9 to 11.2 ng/kg bw/day and in women from 2.5 to 11.5 ng/kg bw/day. The 95th percentile chronic exposure to ZEA was determined in children from 11.9 to 24.9 ng/kg bw/day, in men from 5.9 to 27.5 ng/kg bw/day and in women from 4.8 to 12.6 ng/kg bw/day. The risk linked with the mean and the 95th percentile chronic exposure (LB scenario) to the sum of DON forms, sum of T2/HT2 and ZEA is considered to be out of health concern for the selected population groups.

中文翻译:

谷物食品和啤酒中脱氧雪腐烯醇形式,T-2 / HT-2毒素和玉米赤霉烯酮的膳食摄入评估。

对4-6岁的捷克儿童和18-59岁的捷克和男性进行饮食暴露评估,评估的形式包括脱氧雪腐酚(DON)形式,T-2 / HT-2毒素(T2 / HT2)和玉米赤霉烯酮(ZEA)的总量。年份。通过LC-MS / MS方法评估零售食品(25种不同商品,n = 336)。在648至1030 ng / kg体重/天(LB /下限/和UB /上限/体重)的儿童中确定了DON形式总数的第95个百分率慢性暴露,在362-923 ng / kg bw /天的男性中确定为​​儿童妇女每天体重从272至490 ng / kg体重。在儿童中,T2 / HT2总和的第95个百分位数慢性暴露水平被确定为儿童为6.5至31 ng / kg bw /天,男性为1.9至11.2 ng / kg bw /天,女性为2.5至11.5 ng / kg bw /天。在每天11.9至24.9 ng / kg bw /天的儿童中,从5.9至27岁的男性中,确定了95%的ZEA慢性暴露水平。每天5 ng / kg体重,妇女每天4.8至12.6 ng / kg体重。与DON形式,T2 / HT2和ZEA的总和的平均值和第95个百分位数的慢性暴露(LB情景)相关的风险被认为与选定的人群没有健康关系。
更新日期:2020-03-19
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