Recently, alterations of complexity due to brain disorders have been demonstrated using brain entropy (BEN), while the changes of brain complexity in stroke, a common cerebrovascular disease, remain unclear. In this research, resting-state functional magnetic resonance imaging (fMRI) was performed to explore the alterations of brain complexity using BEN in twenty stroke patients with motor deficits and nineteen matched healthy controls. The sample entropy (SampEn) was applied to build the BEN mapping for each participant. Compared with healthy controls, stroke patients exhibited lower BEN values in the contralesional precentral gyrus (preCG), bilateral dorsolateral frontal gyrus (SFGdor) and bilateral supplementary motor area (SMA). Moreover, significantly positive correlations between BEN values and Fugl-Meyer Assessment scores were detected in the ipsilesional SFGdor and ipsilesional SMA. Mutual information independence was observed between BEN and regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), respectively, in the stroke patients. Our findings implied that brain complexity had been impacted after stroke, and also suggested that BEN could be a complementary tool for evaluating the motor impairment after stroke.

中文翻译：

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运动障碍导致的卒中复杂性降低：一项静息状态fMRI研究。

最近，已经使用脑熵（BEN）证实了由于脑部疾病引起的复杂性改变，而脑卒中是一种常见的脑血管疾病，其脑部复杂性的变化仍不清楚。在这项研究中，进行了静息状态功能磁共振成像（fMRI），以研究使用BEN的20例运动功能障碍的卒中患者和19例健康对照者的大脑复杂性变化。应用样本熵（SampEn）为每个参与者建立BEN映射。与健康对照组相比，中风患者在对侧中央前回（preCG），双侧背外侧额回（SFGdor）和双侧辅助运动区（SMA）的BEN值较低。此外，在同病SFGdor和同病SMA中检测到BEN值与Fugl-Meyer评估评分之间存在显着的正相关。脑卒中患者的BEN与区域同质性（ReHo），低频波动幅度（ALFF）之间存在相互信息独立性。我们的发现表明脑卒中后大脑的复杂性受到了影响，并暗示BEN可以作为评估卒中后运动障碍的补充工具。