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The Endocannabinoid System Contributes to Memory Deficits Induced by Rapid-eye-movement Sleep Deprivation in Adolescent Mice.
Neuroscience ( IF 2.9 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.neuroscience.2020.03.016
Jinming Zhang 1 , Lizi Zhang 2 , Yuan Chang 1 , Qiaofen Gu 1 , Junmin Zhang 1 , Zhou Zhu 3 , Zhaoqiang Qian 1 , Chunling Wei 1 , Zhiqiang Liu 1 , Wei Ren 1 , Jing Han 1
Affiliation  

Sleep loss or insomnia is among the contributing factors of cognitive deficit, the underlying mechanisms of which remain largely elusive. The endocannabinoid (eCB) system plays a role in sleep, while it is unknown if it is involved in the regulation of memory retrieval by sleep deprivation. In addition, it still controversial how rapid-eye-movement sleep deprivation (REMSD) affects the spatial memory of adolescent mice. Here, we found that 24-hour REMSD impairs spatial memory retrieval of adolescent mice in an object-place recognition task, which was rescued by NESS0327, a neutral cannabinoid receptor 1 (CB1R) antagonist. Mechanistically, REMSD induced eCB-mediated short-term and long-term synaptic plasticity changing including depolarization-induced suppression of inhibition (DSI) in the pyramidal neurons of the hippocampus, in which long-term synaptic plasticity changing was rescued by NESS0327. REMSD downregulated monoacylglycerol lipase, a hydrolase for the endocannabinoid 2-arachidonoylglycerol (2-AG), suggesting the involvement of eCB accumulation and the consequent synaptic plasticity in REMSD-elicited memory impairment in adolescent mice. These findings shed light on the role of sleep disorders in learning and memory deficit of adolescents.



中文翻译:

内源性大麻素系统有助于青少年小鼠快速眼动睡眠剥夺所引起的记忆缺陷。

睡眠不足或失眠是认知障碍的诱因之一,其潜在机制仍难以捉摸。内源性大麻素(eCB)系统在睡眠中发挥作用,但尚不清楚它是否参与睡眠剥夺对记忆恢复的调节。此外,仍然存在争议的是快速眼动睡眠剥夺(REMSD)如何影响青春期小鼠的空间记忆。在这里,我们发现24小时REMSD会损害中性大麻素受体1(CB1R)拮抗剂NESS0327拯救的对象位置识别任务中的青春期小鼠的空间记忆检索能力。从机理上讲,REMSD诱导eCB介导的短期和长期突触可塑性改变,包括去极化诱导的海马锥体神经元抑制(DSI)抑制,NESS0327挽救了长期突触可塑性的改变。REMSD下调了单酰基甘油脂肪酶,这是一种内源性大麻素2-花生四烯酸甘油酯(2-AG)的水解酶,表明eCB的积累和突触可塑性参与了REMSD引起的青春期小鼠的记忆障碍。这些发现揭示了睡眠障碍在青少年学习和记忆不足中的作用。

更新日期:2020-03-19
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