There is an ongoing need to develop high-performance sensing strategy for detecting and discriminating antioxidants, primarily because of their role in medical diagnosis and food. In this regard, visual sensor arrays have been a subject of intensive research for such applications. To this end, we propose a colorimetric sensor array for accurate detection and identification of antioxidants, which is based on the reactions between 3,3',5,5'-tetramethylbenzidine (TMB) and metal ions as sensing receptors and the interactions between antioxidants and oxidized TMB (oxTMB). Different target antioxidants displayed diverse reduction abilities toward the oxTMB, creating distinct colorimetric response patterns. The combination of colorimetric response variation at color and absorbance at 652 nm enables the sensor array to provide a unique fingerprint pattern to each antioxidant. Linear discriminant analysis (LDA) and centroid diagrams show that the sensor array can well detect and discriminate the eight tested antioxidants, including lipoic acid (LIA), cysteine (Cys), tannin (TA), ascorbic acid (AA), glutathione (GSH), Uric Acid (UA), glycine (Gly), and dopamine (DA), with a high sensitivity in the range of nanomolar concentrations.

中文翻译：

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比色传感器阵列，用于基于金属离子作为传感器受体的抗氧化剂的准确检测和鉴定。

主要由于抗氧化剂在医学诊断和食品中的作用，因此迫切需要开发一种用于检测和区分抗氧化剂的高性能传感策略。在这方面，视觉传感器阵列已经成为用于此类应用的深入研究的主题。为此，我们基于3,3'，5,5'-四甲基联苯胺（TMB）与作为感应受体的金属离子之间的反应以及抗氧化剂之间的相互作用，提出了一种用于准确检测和鉴定抗氧化剂的比色传感器阵列。和氧化的TMB（oxTMB）。不同的目标抗氧化剂显示出对oxTMB的不同还原能力，从而创建了不同的比色响应模式。颜色的比色响应变化和652 nm处的吸光度的结合使传感器阵列能够为每种抗氧化剂提供独特的指纹图案。线性判别分析（LDA）和质心图显示，该传感器阵列可以很好地检测和区分八种经过测试的抗氧化剂，包括硫辛酸（LIA），半胱氨酸（Cys），单宁（TA），抗坏血酸（AA），谷胱甘肽（GSH） ），尿酸（UA），甘氨酸（Gly）和多巴胺（DA），在纳摩尔浓度范围内具有高灵敏度。