This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern, 320 individuals with early mild cognitive impairment, 171 individuals with late mild cognitive impairment, and 151 individuals with AD, with 3T MRI and CSF Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau) data. Multiple linear regression models assessed the relationship between WMH and CSF Aβ1-42, t-tau, and p-tau. Directionally, a higher WMH burden was associated with lower CSF Aβ1-42 within each diagnostic group, with no evidence for a difference in the slope of the association across diagnostic groups (p = 0.4). Pooling all participants, this association was statistically significant after adjustment for t-tau, p-tau, age, diagnostic group, and APOE-ε4 status (p < 0.001). Age was the strongest predictor of WMH (partial R2~16%) compared with CSF Aβ1-42 (partial R2~5%). There was no evidence for an association with WMH and either t-tau or p-tau. These data are supportive of a link between amyloid burden and presumed vascular pathology.

中文翻译：

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脑脊液淀粉样蛋白是从衰老到阿尔茨海默病的整个疾病过程中白质高信号的一致预测因子

这项研究调查了白质高信号 (WMH) 和脑脊液 (CSF) 阿尔茨海默病 (AD) 生物标志物之间的关系。受试者包括 180 名对照者、107 名有显着记忆问题的人、320 名早期轻度认知障碍患者、171 名晚期轻度认知障碍患者和 151 名 AD 患者，3T MRI 和 CSF Aβ1-42，总 tau (t-tau ) 和磷酸化 tau (p-tau) 数据。多元线性回归模型评估了 WMH 和 CSF Aβ1-42、t-tau 和 p-tau 之间的关系。直接地，在每个诊断组中，较高的 WMH 负荷与较低的 CSF Aβ1-42 相关，没有证据表明不同诊断组之间的关联斜率存在差异（p = 0.4）。汇集所有参与者，在调整 t-tau、p-tau、年龄、诊断组和 APOE-ε4 状态后，这种关联具有统计学意义（p < 0.001）。与CSF Aβ1-42（部分R2~5%）相比，年龄是WMH（部分R2~16%）的最强预测因子。没有证据表明与 WMH 以及 t-tau 或 p-tau 相关。这些数据支持淀粉样蛋白负荷与假定的血管病理之间存在联系。