Therapeutic deep eutectic systems (THEDES) emerged as alternative therapeutic agents that can enhance the bioavailability of the currently used active pharmaceutical ingredients. The use of THEDES in combination with supercritical CO₂ has started to be explored to formulate drug delivery systems through green technology. This work aimed to develop THEDES-delivery systems for tuberculosis therapy, by encapsulating l-arginine-based THEDES in a lipidic matrix, through supercritical CO₂ technology. From the phase equilibrium study of THEDES and CO₂, PGSS was selected for THEDES encapsulation. Herein, THEDES encapsulation through PGSS was accomplished for the first time, with an average encapsulation efficiency of 75 %. The influence of the THEDES water-content in PGSS processing was also studied, suggesting no interference of the THEDES-water content in the formulation of the THEDES particles. Furthermore, the cell viability of the THEDES and the particles with THEDES encapsulated was measured in L929 fibroblasts and the systems prepared were non-cytotoxic.

治疗性深共晶系统（THEDES）作为替代治疗剂出现，可以增强当前使用的活性药物成分的生物利用度。已开始探索将THEDES与超临界CO ₂结合使用以通过绿色技术配制药物递送系统。这项工作旨在通过超临界CO ₂技术将基于l-精氨酸的THEDES封装在脂质基质中，从而开发用于结核病治疗的THEDES递送系统。根据THEDES和CO _2的相平衡研究，选择PGSS进行THEDES封装。在此，首次完成了通过PGSS进行的THEDES封装，平均封装效率为75％。还研究了DESSS含量在PGSS加工中的影响，表明在THEDES颗粒配方中不会干扰THEDES含量。此外，在L929成纤维细胞中测量了THEDES和包封有THEDES的颗粒的细胞生存力，并且所制备的系统是无细胞毒性的。