The increasing number of older people is resulting in an increased prevalence of age-related diseases. Research has shown that the ageing process itself is a potential point of intervention. Indeed, gene expression can be optimised for health in older ages through manipulation of transcription factor (TF) activity. This review is focused on the ever-growing number of TFs whose effects on ageing are evolutionarily conserved. These regulate a plethora of functions, including stress resistance, metabolism, and growth. They are engaged in complex interactions within and between different cell types, impacting the physiology of the entire organism. Since ageing is not programmed, the conservation of their effects on lifespan is most likely a reflection of the conservation of their functions in youth.

中文翻译：

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影响寿命的转录因子的进化保守性。

越来越多的老年人导致与年龄有关的疾病的流行增加。研究表明，老化过程本身就是一个潜在的干预点。实际上，可以通过操纵转录因子（TF）活性来优化基因表达，以提高老年人的健康水平。这项审查的重点是不断增长的TFs，其对衰老的影响在进化上是保守的。这些调节过多的功能，包括抗逆性，新陈代谢和生长。它们参与不同细胞类型内部和之间的复杂相互作用，从而影响整个生物体的生理。由于没有对衰老进行编程，因此保留它们对寿命的影响很可能反映了它们在青年时期的功能保留。